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| 类淋巴系统与围术期神经认知障碍相关性的研究进展 |
| Research progress on correlation of glymphatic system and perioperative neurocognitive disorders |
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| DOI：10.12089/jca.2022.08.017 |
| 中文关键词: 类淋巴系统 脑膜淋巴管 围术期神经认知障碍 水通道蛋白4 老年 |
| 英文关键词: Glymphatic system Meningeal lymphatic vessels Perioperative neurocognitive disorders Aquaporin 4 Aged |
| 基金项目:国家自然科学基金（82171193,82001132,81730033）；十三五强卫工程-重点人才项目（ZDRCA2016069）；南京大学医学院科研与实践创新计划项目（2021） |
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| 中文摘要: |
| 围术期神经认知障碍（PND）是患者在术后出现的人格、社交及认知功能改变，以学习记忆能力下降为主要特征，严重影响患者术后健康状况及生存质量，但目前临床尚缺乏有效防治措施。类淋巴系统是由水通道蛋白4（AQP4）介导的脑脊液转运系统，可清除神经毒性物质，维持大脑内环境稳定。类淋巴系统损伤机制可从大脑废物清除角度综合解释PND的诸多病理生理改变，有望成为干预PND发生发展的集束化靶点。本文对类淋巴系统的研究进展及类淋巴系统与PND相关诱发因素间的潜在联系进行综述，以期为PND的防治提供新思路。 |
| 英文摘要: |
| Perioperative neurocognitive disorders (PND) is a common central nervous system complication after surgery, characterized by disorders of social and communication skills, cognitive processes and personality. PND severely impairs prognosis and life quality, and there are few effective clinical interventions to prevent this disorder. The glymphatic system is a brain-wide CSF transport system mediated by aquaporin 4 (AQP4), which plays an important role in the clearance of extracellular metabolites and waste products in the brain. The mechanism of glymphatic system dysfunction can explain the multiple pathological alterations of PND from the perspective of brain waste removal, and it is expected to be a promising therapeutic target for preventing and treating PND. This review summarizes current knowledge of the function of glymphatic system and its potential link with PND, and provides new ideas for the prevention and control of PND. |
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