Objective To investigate the effect of lung-protective ventilation in elderly female patients undergoing laparoscopic radical resection of endometrial carcinoma.
Methods Sixty elderly female patients undergwent laparoscopic radical resection of endometrial carcinoma from June 2019 to June 2020, aged 65-80 years, BMI 20-28 kg/m2, ASA physical status Ⅰ or Ⅱ, were divided into 2 groups using random number table: protective ventilation group (group P) and regulation ventilation group (group R), 30 patients in each group. In group P, the tidal volume (VT) was set at 7 ml/kg, PEEP was set at 7 cmH2O, and regular recruitment maneuvers (RM) once every 30 minutes. In group R, the VT was set at 9 ml/kg, whereas PEEP and RM were not used. The airway peak pressure (Ppeak), airway plateau pressure (Pplat), dynamic lung compliance (Cdyn) and concentrations of IL-6, IL-8, and TNF-α in serum were recorded before pneumoperitoneum, 2 hours after pneumoperitoneum and immediately after operation. The oxygen index (PaO2/FiO2) was recorded before pneumoperitoneum and immediately leaving the recovery room.
Results Compared with before pneumoperitoneum, the Ppeak, Pplat, concentrations of IL-6, IL-8 and TNF-α increased 2 hours after pneumoperitoneum and immediately after operation (P < 0.05), and the Cdyn decreased, PaO2/FiO2 decreased immediately after leaving the recovery room in both groups (P < 0.05). Compared with group R, the Ppeak, Pplat, concentrations of IL-6, IL-8 and TNF-α decreased (P < 0.05) and the Cdyn increased 2 hours after pneumoperitoneum and immediately after operation, PaO2/FiO2 increased immediately after leaving the recovery room in group P (P < 0.05).
Conclusion Lung-protective ventilation can relieve perioperative respiratory function injury and the inflammation in elderly patients undergoing laparoscopic radical resection of endometrial carcinoma. |
