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| 七氟醚对脂多糖致热大鼠体温的影响 |
| Effects of sevoflurane on body temperature of fever rats induced by lipopolysaccharide |
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| DOI：10.12089/jca.2019.11.016 |
| 中文关键词: 七氟醚 体温 脂多糖 短暂重复性麻醉 |
| 英文关键词: Sevoflurane Body temperature Lipopolysaccharide Transient repeated anesthesia |
| 基金项目:国家中医药防治传染病重点研究室建设项目［国中医药函(2010)34号］；天津市卫生健康委员会天津市中医药管理局中医中西医结合科研课题（2019132） |
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| 中文摘要: |
目的 观察七氟醚短暂重复性麻醉脂多糖致热大鼠的体温变化,探讨七氟醚调节体温的可能作用机制。
方法 健康SD雄性大鼠24只,体重210～230 g,随机分为三组:空白对照组(C组)、模型组(M组)、模型+七氟醚组(S组),每组8只。C组腹腔注射0.9％氯化钠注射液(10 ml/kg),M组腹腔注射脂多糖(LPS)20 μg/kg制备大鼠发热模型,S组腹腔注射LPS(20 μg/kg)后,每隔1 h置入1.5％七氟醚麻醉罐中麻醉,每次吸入30 s～1 min。造模后每隔30 min平行监测三组大鼠体温1次,共监测10 h。记录三组大鼠的生理情况、体温、体温升高时点、体温峰值、体温峰值时点。记录体温升高持续时间<10 h和≥10 h发生情况。
结果 M组和S组注射LPS后都出现体温升高,有寒颤、竖毛、蜷缩精神萎靡等表现,个别出现轻微腹泻。M组和S组均表现为三相热,S组体温升高时点明显晚于M组(P<0.05),S组体温峰值明显高于M组(P<0.05),体温峰值时点明显晚于M组(P<0.05)。M组和S组体温峰值明显高于C组(P<0.05),体温峰值时点均明显晚于C组(P<0.05)。M组和S组体温升高持续时间(≥10 h)的比例分别为37.5％、87.5％,两组差异无统计学意义。
结论 七氟醚短暂重复性麻醉脂多糖致热大鼠,可推迟大鼠体温升高和体温峰值时点且可升高体温峰值,机制有待于进一步研究。 |
| 英文摘要: |
Ojective To observe the changes of body temperature in lipopolysaccharide-induced fever rats after transient repeated anesthesia with sevoflurane, and to explore the possible mechanism of sevoflurane in regulating body temperature.
Methods Twenty-four healthy SD male rats, weighing 210-230 g, were randomly divided into three groups (n = 8): blank control group (group C), model group (group M), model+sevoflurane group (group S). Group C was intraperitoneally injected with 0.9％ sodium chloride injection (10 ml/kg), group M was intraperitoneally injected with LPS (20 μg/kg) to prepare rat fever model, and group S was intraperitoneally injected LPS (20 μg/kg) and anesthetized in 1.5％ sevoflurane anesthesia tank for 30 s to 1 min every 1 h. After modeling, the body temperature of the three groups of rats was monitored once every 30 min for a total of 10 h. The physiological condition, body temperature, time point of temperature rise, peak temperature and time point of peak temperature of the three groups were recorded. The duration of temperature rise <10 h and ≥10 h were recorded.
Results After LPS injection, both group M and group S showed elevated body temperature, with the performance of chills, bristles, curled up and listlessness. Individuals developed mild diarrhea. Both group M and group S showed three-phase heat. The time point of temperature rise in group S was significantly later than that in group M (P<0.05), the peak temperature of group S was significantly higher than that in group M (P<0.05), the time point of peak temperature in group S was significantly later than that in group M (P<0.05). The peak temperature of group M and group S was significantly higher than that of group C (P<0.05), and the time point of peak temperature was significantly later than that of group C (P<0.05). The proportion of body temperature elevation duration (≥10 h) in group M and group S was 37.5％ and 87.5％, respectively. There was no significant difference between the two groups.
Conclusion The transient repeated anesthesia of sevoflurane in rats with LPS can delay the increase of body temperature and the peak temperature of the body and increase the peak temperature. The mechanism needs further study. |
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