| 【Abstract】 Objective To investigate the effect of ultrasound-guided erector spinae plane block (ESPB) on early postoperative respiratory function and inflammatory cytokines in patients with multiple rib fractures (MRFs). Methods Fifty-eight patients, aged 18-64 years, 42 males and 16 females, ASA physical status I or II, who underwent MRFs surgery were selected from February 2019 to December 2021. The patients were divided into two groups using random number method: ESPB combined with general anesthesia group (group E) and general anesthesia alone group (group G). All patients in group E underwent ultrasound-guided ESPB in the lateral decubitus position after general anesthesia induction, and 0.5% ropivacaine 0.4 ml/kg was administered. Forced vital capacity (FVC), arterial blood gas analysis, VAS scores at rest and cough were recorded before operation, at discharge from PACU, 24 and 48 h after operation. The number of effective PCIA compressions during 0-24 h and 24-48 h after surgery and the rate of rescue analgesia were recorded. The concentrations of IL-6 and TNF-α in the two groups were recorded before operation, 24 and 48 h after operation. Results Compared with group G, the FVC was significantly higher, and the VAS score and PaCO2 were significantly lower in group E at discharge from PACU, 24 and 48 h after operation (P<0.05). The number of effective PCIA compressions during 0-24 h and 24-48 h after surgery, the rate of rescue analgesia, the concentrations of IL-6 and TNF-α at 24 and 48 h after operation in group E were significantly lower than those in group G (P<0.05). Conclusion Ultrasound-guided ESPB can provide good postoperative analgesia, promote early postoperative recovery of respiratory function and reduce inflammatory response in patients with MRFs. |
