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| 自噬在围术期神经认知障碍中作用的研究进展 |
| Research progress on the mechanism of autophagy's role in perioperative neurocognitive disorders |
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| DOI：10.12089/jca.2024.02.018 |
| 中文关键词: 围术期神经认知障碍 麻醉 自噬 |
| 英文关键词: Perioperative neurocognitive disorders Anaesthesia Autophagy |
| 基金项目:国家自然科学基金（82260973） ；甘肃省重点研发计划-社会发展类（20YF3FA020） |
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| 中文摘要: |
| 围术期神经认知障碍常表现为患者记忆力受损及精神错乱，住院时间延长，预后不良以及死亡率上升等。自噬与围术期神经认知障碍的发病密切相关，药物、衰老、炎症等可通过调控mTOR、FOXO1等信号转导通路影响自噬水平，参与围术期神经认知障碍的发病过程。自噬通过调节神经炎症的发生，α-突触核蛋白、τ蛋白代谢等在改善术后认知障碍和学习记忆功能方面发挥重要作用。本文就调控自噬的主要通路及自噬在围术期神经认知障碍发生发展中的作用进行综述，以期为围术期神经认知障碍的发病机制寻求新的靶点和思路。 |
| 英文摘要: |
| Perioperative neurocognitive disorders commonly manifest as impaired memory and confusion in patients, prolonged hospitalisation, poor prognosis, and increased mortality. Autophagy is closely related to the onset of perioperative neurocognitive disorder. Drugs, aging and inflammation affect autophagy levels by regulating signaling pathways such as mTOR and FOXO1, which are involved in the pathogenesis of perioperative neurocognitive disorder. Autophagy plays an important role in improving postoperative cognitive dysfunction and learning memory by modulating neuroinflammation, α-synuclein, and τ protein metabolism. This article reviews the main pathways regulating autophagy and the role of autophagy in the occurrence and development of perioperative neurocognitive disorders, in order to seek new targets and ideas for the pathogenesis of perioperative neurocognitive disorders. |
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