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| 过氧化物酶体增殖物激活受体-γ在神经病理性疼痛中作用的研究进展 |
| Research progress on role of peroxisome proliferator-activated receptor-γ in neuropathic pain |
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| DOI：10.12089/jca.2024.01.016 |
| 中文关键词: 过氧化物酶体增殖物激活受体-γ 神经病理性疼痛 神经炎症 氧化应激 |
| 英文关键词: Peroxisome proliferator-activated receptor-γ Neuropathic pain Neuroinflammation Oxidative stress |
| 基金项目:国家自然科学基金青年项目（8220053407） |
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| 中文摘要: |
| 神经病理性疼痛（NP）由躯体感觉神经系统的损伤或疾病引起，其病理机制复杂，主要与神经结构及功能异常有关，现有治疗手段难以取得满意效果。随着对过氧化物酶体增殖物激活受体-γ（PPAR-γ）的深入研究，其在神经炎症、氧化应激、离子通道、线粒体功能、神经保护等方面的作用陆续被发现，并有望成为疼痛预防与治疗新靶点。本文就PPAR-γ在NP中的作用及机制作一综述，以期为NP的临床治疗提供新思路。 |
| 英文摘要: |
| Neuropathic pain (NP) is caused by leision or disease of the somatic sensory nervous system, and its pathological mechanism is complex, mainly related to abnormal neural structure and function. It is hard for existing treatment methods to obtain satisfactory results. With the deepening of the study of peroxisome proliferate activation receptor-γ (PPAR-γ), its role in neuroinflammation, oxidative stress, ion channels, mitochondrial function, neuroprotection and other aspects have been discovered successively, PPAR-γ may be one new target for pain prevention and treatment. This paper reviews the role of PPAR-γ in NP and related mechanisms, in order to provide new thinking for the clinical treatment of NP. |
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