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| 微粒在脓毒症相关急性肾损伤中作用的研究进展 |
| Research progress on effect of microparticles in sepsis-associated acute kidney injury |
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| DOI：10.12089/jca.2025.08.013 |
| 中文关键词: 脓毒症 微粒 急性肾损伤 脓毒症相关急性肾损伤 |
| 英文关键词: Sepsis Microparticle Acute kidney injury Sepsis-associated acute kidney injury |
| 基金项目:湖北省卫生健康委员会面上项目（WJ2021M144） |
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| 中文摘要: |
| 脓毒症是宿主对感染反应失调而引起的严重器官功能障碍，常合并急性肾损伤，死亡率较高且预后差。微粒是由质膜向外出芽和裂变并释放到细胞外的微囊泡，可携带microRNA、转录因子、细胞因子等，参与各种疾病的发生发展。相关研究表明，微粒参与了脓毒症相关急性肾损伤的病理生理过程，且可能是潜在的生物学标志物。本文就微粒参与脓毒症相关急性肾损伤的研究进行综述，以期为临床治疗策略和预防靶点的研究提供参考。 |
| 英文摘要: |
| Sepsis is characterized by a dysregulated host response to infection that leads to life-threatening organ dysfunction, commonly accompanying acute kidney injury (AKI), with a high mortality rate and poor prognosis. Microparticles are cystic vesicles produced by the plasma membrane to the outgoing bud and released into the cell, carrying microRNAs, transcription factors, and cytokines that are involved in the occurrence and development of diseases. Related studies have found that microparticles are involved in the pathophysiological process of sepsis-associated acute kidney injury and may serve as a potential biomarker. This review summarizes the current research on the role of microparticles in sepsis-associated AKI, to provide references for the research on clinical treatment strategies and preventive targets. |
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