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| 线粒体功能障碍在血脑屏障破坏导致老年患者围术期神经认知障碍中作用的研究进展 |
| Research progress on mitochondrial dysfunction in blood-brain barrier disruption causing perioperative neurocognitive disorders in elderly patients |
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| DOI：10.12089/jca.2025.03.013 |
| 中文关键词: 围术期神经认识障碍 血脑屏障 线粒体功能障碍 老年 |
| 英文关键词: Perioperative neurocognitive disorders Blood-brain barrier Mitochondrial dysfunction Aged |
| 基金项目:国家自然科学基金（82071179） |
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| 中文摘要: |
| 随着接受手术治疗的老年人口数量逐年增加，围术期神经认知障碍（PND）日益受到社会关注。血脑屏障是控制物质进出大脑的重要通道，当血脑屏障受到损害时，有害物质进入大脑，影响大脑功能。血脑屏障破坏是老年患者发生PND的重要机制。线粒体功能障碍可能会导致血脑屏障破坏，包括氧化压力和能量代谢等方面。本文就线粒体功能障碍在血脑屏障破坏导致的PND的发生和发展中的作用进行综述。 |
| 英文摘要: |
| With the number of elderly population receiving surgical treatment increasing year by year, perioperative neurocognitive disorders (PND) is increasingly attracting social attention. The blood-brain barrier is an important channel to control substances in and out of the brain. When the blood-brain barrier is damaged, harmful substances enter the brain and affect the brain function. Blood-brain barrier disruption is an important mechanism for developing PND in elderly patients. Mitochondrial dysfunction may contribute to blood-brain barrier disruption, including aspects such as oxidative stress and energy metabolism. This review summarizes the role of mitochondrial dysfunction in the development and development of PND due to blood-brain barrier disruption. |
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