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| 不同剂量磷丙泊酚二钠在老年患者全麻诱导期镇静效果的比较 |
| Comparison of different doses of fospropofol disodium on sedation effects during induction of general anesthesia in elderly patients |
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| DOI：10.12089/jca.2025.03.001 |
| 中文关键词: 磷丙泊酚二钠 老年 全身麻醉 诱导期 安全性 |
| 英文关键词: Fospropofol disodium Aged General anesthesia Induction period Safety |
| 基金项目:安徽省高校优秀青年人才支持项目（gxyq2022010） |
| 作者 | 单位 | E-mail | | 李薇 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | | | 杨秀丽 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | | | 刘伟钜 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | | | 宁静文 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | | | 王宸 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | | | 刘学胜 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | | | 沈启英 | 230000,合肥市,安徽医科大学第一附属医院麻醉科 | shenqiying@ahmu.edu.cn |
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| 中文摘要: |
目的： 探讨不同剂量磷丙泊酚二钠在老年患者全麻诱导期的镇静效果和安全性。
方法：选择择期行全麻手术的老年患者100例，男43例，女57例，年龄65～89岁，BMI 18.5～28.0 kg/m2 ，ASA Ⅰ—Ⅲ级。采用随机数字表法将患者分为四组：丙泊酚1.5 mg/kg组（C组）和磷丙泊酚二钠10 mg/kg组（F1组）、12.5 mg/kg组（F2组）和15 mg/kg组（F3组），每组25例。C组麻醉诱导给予丙泊酚1.5 mg/kg；F1组、F2组和F3组分别给予磷丙泊酚二钠10、12.5和15 mg/kg。记录首次给药后5 min的镇静成功率、镇静成功时间和意识消失时间。记录单次给药后10 min内低血压和心动过缓及术中注射痛、瘙痒和感觉异常等不良事件的发生情况。
结果：与C组比较，F1组首次给药镇静成功率明显降低（P＜0.05），与F1组比较，F3组镇静成功率明显升高（P＜0.05）。F3组首次给药镇静成功率不劣于C组［0.00%（95%CI -10.86%～10.86%）］。与C组比较，F1组、F2组和F3组意识消失时间明显延长（P＜0.05），F1组、F2组和F3组注射痛发生率明显降低，F2组瘙痒发生率明显升高，F3组异常感觉发生率明显升高（P＜0.05）。F1组、F2组和F3组意识消失时间、低血压和心动过缓发生率差异无统计学意义。
结论： 磷丙泊酚二钠12.5 mg/kg和15 mg/kg均可为老年患者提供满意的镇静效果，且不良事件发生率较低。 |
| 英文摘要: |
Objective: To explore the efficacy and safety of different doses of fospropofol disodium during the induction period of general anesthesia in elderly patients.
Methods: One hundred elderly patients, 43 males and 57 females, aged 65-89 years, BMI 18.5-28.0 kg/m2 , ASA physical status Ⅰ-Ⅲ, scheduled for elective surgery under general anesthesia were enrolled. Patients were randomly divided into four groups: propofol 1.5 mg/kg group (group C), fospropofol disodium 10 mg/kg group (group F1), 12.5 mg/kg group (group F2), and 15 mg/kg group (group F3), 25 patients in each group. General anesthesia was induced with propofol 1.5 mg/kg, fospropofol disodium 10, 12.5 and 15 mg/kg in groups C, F1, F2, and F3, respectively. The success rate of sedation was recorded 5 minutes after the first dose. The successful sedation time, loss of consciousness time, the occurrence of hypotension, bradycardia within 10 minutes after a single dose, and adverse events such as injection pain, itching and abnormal sensation during the operation were recorded.
Results: Compared with group C, the success rate of sedation in group F1 was significantly lower (P < 0.05). Compared with group F1, the success rate of sedation was significantly increased in group F3 (P < 0.05). The success rate of sedation in group F3 was not inferior to that of group C [0.00%(95% CI -10.86% to 10.86%)]. The time of loss of consciousness in groups F1, F2 and F3 was significantly longer than that in group C (P < 0.05). Compared with group C, the incidence of injection pain in groups F1, F2 and F3 was significantly decreased, and the incidence of pruritus in group F2 was significantly increased, the incidence of paresthesia in group F3 was significantly increased (P < 0.05). However, there were no statistically significant differences in the time of loss of consciousness and the incidence of hypotension and bradycardia among groups F1, F2 and F3.
Conclusion: During general anesthesia induction in elderly patients, 12.5 mg/kg and 15 mg/kg of fospropofol disodium could provide satisfactory sedation with a low incidence of adverse events. |
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