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| 环泊酚用于脑肿瘤手术患者麻醉诱导的有效性和安全性 |
| Efficacy and safety of ciprofol for anesthesia induction in patients undergoing brain tumor surgery |
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| DOI：10.12089/jca.2025.02.005 |
| 中文关键词: 环泊酚 丙泊酚 脑肿瘤 麻醉诱导 有效性 安全性 |
| 英文关键词: Ciprofol Propofol Brain tumor Anesthesia induction Efficacy Safety |
| 基金项目:江苏省重点研发计划项目（BE2022049）；江苏省重点研发计划产业前瞻与关键技术项目课题（BE2022049-1） |
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| 中文摘要: |
目的：探讨环泊酚用于脑肿瘤手术患者麻醉诱导的有效性和安全性。
方法：选择2023年7月至2024年4月择期全麻下行脑肿瘤切除术患者117例，男60例，女57例，年龄18～64岁，BMI 18.5～30.0 kg/m2，ASA Ⅰ—Ⅲ级。采用随机数字表法将患者分为两组：环泊酚组（C组，n=59）和丙泊酚组（P组，n=58）。C组使用环泊酚0.4 mg/kg进行麻醉诱导，P组使用丙泊酚2.0 mg/kg进行麻醉诱导。记录麻醉诱导成功例数、麻醉诱导时间、睫毛反射消失时间；记录麻醉诱导后1 min的Narcotrend指数；记录麻醉诱导过程中循环系统相关不良反应（包括低血压、高血压、心动过缓、心动过速）、呼吸系统相关不良反应（包括低血氧饱和度、呼吸抑制、缺氧、支气管痉挛、呛咳）以及喉痉挛、呃逆、不自主运动反应（肌颤搐和肌阵挛）、镇静过深（Narcotrend指数<13）、镇静不足（Narcotrend指数>64）、注射痛等其他不良反应。
结果：两组麻醉诱导成功率均为100%。两组麻醉诱导时间、睫毛反射消失时间差异无统计学意义。两组麻醉诱导时间平均差值的95%CI下限为1.6783，大于非劣效界值-5。与P组比较，C组低血压、低血氧饱和度、呛咳以及注射痛发生率明显降低（P<0.05）。
结论：环泊酚应用于脑肿瘤手术麻醉诱导的效果不劣于丙泊酚，且对循环、呼吸影响更小、注射痛更少，具有一定的有效性以及安全性。 |
| 英文摘要: |
Objective: To investigate the efficacy and safety of ciprofol in anesthesia induction in patients undergoing brain tumor surgery.
Methods: A total of 117 patients with brain tumor resection under elective general anesthesia from July 2023 to April 2024 were selected, including 60 males and 57 females, aged 18-64 years, BMI 18.5-30.0 kg/m2, and ASA physical statusⅠ-Ⅲ. According to random number table method, the patients were divided into two groups: ciprofol group (group C, n = 59) and propofol group (group P, n = 58). Group C was induced by ciprofol 0.4 mg/kg, and group P was induced by propofol 2.0 mg/kg. The number of successful anesthesia induction cases, the induction time of anesthesia, and the disappearance time of eyelash reflex were recorded. The Narcotrend index 1 minute after induction was recorded. Circulatory adverse reactions (including hypotension, hypertension, bradycardia, and tachycardia), respiratory adverse reactions (including low blood oxygen saturation, respiratory depression, hypoxia, bronchospasm, and coughing), and other adverse reactions including laryngeal spasm, hiccup, involuntary motor reactions (myokymia and myoclonus), excessive calmness (Narcotrend index < 13), insufficient calmness (Narcotrend index > 64), and injection pain were recorded.
Results: The induction success rate of general anesthesia in both groups was 100%. There was no significant difference in the induction time of anesthesia and the disappearance time of eyelash reflex between the two groups. The lower limit of 95% CI (1.6783) of the average difference of anesthesia induction time between the two groups was greater than the non-inferiority threshold (-5). Compared with group P, the incidence of adverse reactions such as hypotension, low blood oxygen saturation, cough and injection pain in group C was significantly decreased (P < 0.05).
Conclusion: The sedation effect of ciprofol which is effective and safe in brain tumor surgery is not inferior to that of propofol, and can achieve less impact on circulation and respiration, with less injection pain. The anesthesia induction of ciprofol combined with sufentanil has certain efficacy and safety. |
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