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| 衰弱患者能量代谢改变及围术期干预的研究进展 |
| Research progress on energy metabolism changes in frail patients and perioperative interventions |
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| DOI：10.12089/jca.2024.11.018 |
| 中文关键词: 衰弱 糖代谢 脂质代谢 氨基酸代谢 围术期 |
| 英文关键词: Frailty Glucose metabolism Fat metabolism Amino acid metabolism Perioperative period |
| 基金项目:上海市“科技创新行动计划”计算生物学重点专项（23JS1400100） |
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| 中文摘要: |
| 衰弱是一种临床综合征，表现为机体多脏器功能逐渐下降，出现脆弱表型。衰弱患者应激抵抗能力减弱，术后多出现不良结局，包括认知功能下降、住院时间延长、并发症发生率以及死亡率上升。由于衰弱是一个动态可逆的过程，因此，提倡在围术期采取适当的优化措施，以改善患者预后。近年来研究表明能量代谢异常在衰弱发生和发展中发挥重要作用。本文将重点探讨衰弱患者在糖代谢、脂质代谢和氨基酸代谢方面的异常，以及围术期纠正衰弱患者能量代谢异常的重要性，旨在为降低围术期并发症、提高手术安全性提供参考。 |
| 英文摘要: |
| Frailty is a clinical syndrome characterized by the gradual decline of multiple organ function and the emergence of vulnerable phenotype. Patients with frailty exhibit diminished resistance to stress, which often leads to unfavorable outcomes following surgery, including cognitive decline, prolonged hospitalization, and increased rates of complications and mortality. Given that frailty is a dynamic and reversible process, it is recommended to implement appropriate optimization measures during the perioperative period in order to improve patient outcomes. Recent studies have revealed that abnormal energy metabolism plays a crucial role in the development and occurrence of frailty. This article will primarily focus on abnormalities in glucose metabolism, lipid metabolism, and amino acid metabolism among frail patients, and emphasize the significance of correcting these metabolic irregularities during the perioperative period in order to reduce complications and improving surgical safety. |
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