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| 术中液体治疗对内皮糖萼脱落影响的研究进展 |
| Research progress on the effect of intraoperative fluid therapy on endothelial glycocalyx shedding |
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| DOI：10.12089/jca.2024.10.016 |
| 中文关键词: 液体治疗 内皮糖萼 晶体 胶体 |
| 英文关键词: Fluid therapy Endothelial glycocalyx Crystals Colloids |
| 基金项目: |
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| 中文摘要: |
| 内皮糖萼（EG）是血管内皮屏障的重要组成部分，在体液稳态、炎症反应调节、维持血管通透性、血小板和白细胞粘附过程中起关键作用。创伤、炎症、感染和医源性干预是EG脱落的重要原因。液体治疗是麻醉科医师围术期管理的重要组成部分，根据不同的患者选择适当的液体类型和液体输注策略可能有助于降低术后并发症的发生率，改善患者预后。本文对EG的结构和生理特性进行阐述，对术中液体治疗的现状进行归纳，并探讨术中液体治疗对EG的影响以及液体治疗的优化对EG的保护作用，为术中液体治疗提供参考。 |
| 英文摘要: |
| The endothelial glycocalyx (EG) is an important component of the vascular endothelial barrier and plays a key role in fluid homeostasis, regulation of inflammatory responses, maintenance of vascular permeability, and platelet and leukocyte adhesion. Trauma, inflammation, infection, and medical interventions are important causes of EG shedding. Fluid therapy is an important part of perioperative management for anesthesiologists, and the selection of appropriate fluid types and fluid infusion strategies for different patients may help reduce the incidence of postoperative complications and improve patient prognosis. In this article, we describe the structure and physiological properties of the endothelial glycocalyx, summarize the current status of intraoperative fluid therapy, and discuss the effects of intraoperative fluid therapy on the endothelial glycocalyx, as well as the protective effects of fluid therapy optimization on the endothelial glycocalyx, in order to provide a reference for intraoperative fluid therapy. |
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