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| 微小RNA参与调控围术期神经认知障碍的研究进展 |
| Research progress of microRNA involved in perioperative neurocognitive disorders regulation |
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| DOI：10.12089/jca.2024.10.013 |
| 中文关键词: 微小RNA 围术期神经认知障碍 神经炎症 疼痛 |
| 英文关键词: MicroRNA Perioperative neurocognitive disorders Neuroinflammation Pain |
| 基金项目:湖南省研究生科研创新项目（CX20231006）；南华大学第二批“4310”立项项目（20224310NHYCG08）；南华大学科研重点指导项目（USCKF201902K01） |
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| 中文摘要: |
| 围术期神经认知障碍（PND）是围术期常见的并发症之一，尤其是在老年患者中，PND发病率高且与手术预后密切相关。目前PND公认的发病机制主要有中枢神经炎症反应、突触功能障碍、细胞凋亡、氧化应激、Aβ过度沉积等。微小RNA（miRNA）作为神经系统发育和功能调节的关键基因表达调控因子，不仅直接参与这些过程的调控，同时还通过参与调控微生物菌群-肠-脑轴、围术期情绪调节以及术后疼痛，间接影响PND的发生。本文对miRNA在调控PND中的作用进行综述，旨在为PND的诊断、预防以及开发该疾病的靶向治疗药物提供参考。 |
| 英文摘要: |
| Perioperative neurocognitive disorders (PND) is one of the common complications in the perioperative period, especially in elderly patients, and the incidence of PND is high and it is closely related to the prognosis of surgery. The currently accepted pathogenesis of PND includes central nervous system inflammation, synaptic dysfunction, apoptosis, oxidative stress, and neurofibrillary tangles, etc. MicroRNAs (miRNAs), as key gene expression regulators of neurological development and function, are not only directly involved in these processes, but also indirectly affect PND development through the modulation of the microbiota-gut-brain axis, perioperative mood regulation, and postoperative pain. In this paper, we review the role of miRNA in regulating perioperative neurocognitive disorders, with the aim of providing new ideas for the diagnosis and prevention of PND, as well as for the development of targeted therapies for this disease. |
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