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| 糖尿病患者骨科手术后糖代谢异常与术后神经认知功能障碍相关性的研究进展 |
| Research progress on the correlation between abnormal glucose metabolism and postoperative neurocognitive disorders in diabetic patients after orthopedic surgery |
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| DOI：10.12089/jca.2024.08.018 |
| 中文关键词: 糖尿病 糖代谢 骨科手术 术后神经认知功能障碍 |
| 英文关键词: Diabetes Glucose metabolism Orthopedic surgery Postoperative neurocognitive disorders |
| 基金项目:国家临床重点学科（〔2011〕170）；重庆市医学重点学科（〔2007〕2） |
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| 中文摘要: |
| 术后神经认知功能障碍（NCD）是指患者在术后出现认知、记忆、定向力等能力下降的神经系统退行性病变。随着社会老龄化发展，多数老年患者由于衰老、行动不便等因素往往会经历骨科手术，这类手术刺激强、时间长，患者术后NCD的发生率较高。糖尿病是老年群体中较常见的慢性疾病，并且大多数会出现认知功能下降等中枢神经系统损伤性反应。因此，老年糖尿病患者在手术后由于自身糖代谢异常、手术刺激及麻醉药物的影响，往往更容易出现术后谵妄或术后认知功能障碍等神经系统并发症，因退行性变是一个慢性病理过程，会导致患者预后不良、医疗成本增加、生活质量下降等不良后果。本文主要通过讨论糖尿病患者糖代谢异常与术后NCD发生发展的关系，进而探讨糖代谢异常在患者骨科术后NCD发生中的作用和影响。 |
| 英文摘要: |
| Postoperative neurocognitive disorders (NCD) refer to degenerative diseases of the nervous system in which patients have reduced cognition, memory, orientation, and other abilities after surgery. With the development of social aging, most of the elderly often experience orthopedic surgery due to factors such as aging and inconvenience, which are highly stimulating and time-prolonging, and the incidence of postoperative NCD is high. Diabetes mellitus is a common chronic disease in older age groups, and most of them cause central nervous system damage such as cognitive decline. Therefore, elderly diabetic patients are often more likely to have neurological complications such as postoperative delirium or postoperative cognitive dysfunction due to abnormal glucose metabolism, surgical stimulation and the influence of anesthetic drugs after surgery, because degeneration is a chronic pathological process, which will lead to adverse consequences such as poor prognosis, increased medical costs, and decreased quality of life. This article mainly discusses the relationship between abnormal glucose metabolism and the occurrence and development of NCD in diabetic patients, and then explores the role and influence of abnormal glucose metabolism in the occurrence of NCD after orthopedic surgery. |
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