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| 去甲肾上腺素与系统性免疫炎症指数相关性的研究进展 |
| Research progress on the correlation between norepinephrine and systemic immune inflammation index |
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| DOI：10.12089/jca.2024.08.014 |
| 中文关键词: 系统性免疫炎症指数 去甲肾上腺素 围术期 预后 炎症反应 β2肾上腺素能受体 |
| 英文关键词: Systemic immune inflammation index Norepinephrine Perioperative period Prognosis Inflammatory response β2 adrenergic receptors |
| 基金项目:国家自然科学基金（82060581） |
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| 中文摘要: |
| 围术期的管理与术后并发症的发生有着密不可分的联系。术后较高炎症水平会导致术后并发症的发生率及死亡率增加。系统性免疫炎症指数（SII）是一种新提出的系统免疫炎症反应标记物，能更好地反映炎症水平，术中维持较低水平SII能极大减少术后并发症的发生、促进疾病恢复并降低死亡率等。去甲肾上腺素（NE）具有抑制炎症反应的功能，通过β2肾上腺素能受体抑制促炎因子的合成与释放，同时促进抗炎因子白细胞介素-10（IL-10）的分泌。因此，本综述从去甲肾上腺素作用机制、NE与全身SII水平的关系进行阐述，进一步探讨去甲肾上腺素通过调节炎症细胞对SII的影响。 |
| 英文摘要: |
| Perioperative management and protection are inextricably linked to the occurrence of postoperative complications. Higher levels of postoperative inflammation are associated with increased postoperative complications and mortality. Systemic immune-inflammation index (SII) is a newly proposed systemic immune inflammatory response marker, which can better respond to the level of inflammation, and maintaining a low level of SII during surgery can greatly reduce the occurrence of postoperative complications, promote disease recovery, and reduce mortality. Norepinephrine (NE) has the function of inhibiting inflammatory response, inhibiting the synthesis and release of pro-inflammatory factors through β2-adrenergic receptors, and promoting the secretion of anti-inflammatory factor IL-10. Therefore, this review elaborates on the mechanism of action of norepinephrine and the relationship between NE and systemic SII levels, and further explores the effect of norepinephrine on SII by regulating inflammatory cells. |
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