|
| Wnt信号通路参与周围神经病理性疼痛的研究进展 |
| Research progress on the mechanism of Wnt signaling pathway in peripheral neuropathic pain |
| |
| DOI：10.12089/jca.2024.04.013 |
| 中文关键词: Wnt信号通路；周围神经病理性疼痛；慢性疼痛；外周敏化 中枢敏化 |
| 英文关键词: Wnt signaling pathway Peripheral neuropathic pain Chronic pain Peripheral sensitization Central sensitization |
| 基金项目:国家自然科学基金（82071252，82271262） |
| 作者 | 单位 | E-mail | | 朱贺 | 100730,中国医学科学院,北京协和医学院,北京协和医院麻醉科 | | | 闻蓓 | 100730,中国医学科学院,北京协和医学院,北京协和医院麻醉科 | | | 许力 | 100730,中国医学科学院,北京协和医学院,北京协和医院麻醉科 | | | 黄宇光 | 100730,中国医学科学院,北京协和医学院,北京协和医院麻醉科 | huangyg@pumch.cn |
|
| 摘要点击次数: 150 |
| 全文下载次数: 77 |
| 中文摘要: |
| 神经病理性疼痛是由躯体感觉系统的损伤或疾病引起的疼痛综合征，临床上周围神经病理性疼痛（pNP）较为常见，主要表现为自发痛、痛觉超敏、痛觉过敏和感觉异常等，其发病机制较为复杂且存在争议。目前临床治疗以药物为主，效果欠佳且不良反应较多。Wnt信号通路在神经发育中对细胞增殖分化起重要作用，可通过调控神经损伤修复参与pNP的发生。本文就Wnt信号通路与pNP的联系进行综述，旨在为寻找更为安全有效的治疗靶点提供指导依据。 |
| 英文摘要: |
| Neuropathic pain is the pain syndrome caused by damage or disease of the somatosensory system, clinically, the common type is peripheral neuropathic pain (pNP), mainly manifested as spontaneous pain, allodynia, hyperalgesia and paresthesia, with complex and controversial pathogenesis. At present, clinical treatment is mainly based on drugs, with poor effect and more adverse events. Wingless-type MMTV integration site family (Wnt) signaling pathway plays an important role in cell proliferation and differentiation in neurodevelopment and can participate in the occurrence of pNP by regulating nerve injury repair. This article reviews the relationship between Wnt signaling pathway and pNP, in order to provide guidance for more safe and effective therapeutic targets. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
