Rapid sequence induction and intubation (RSII) is a protective process in patients at high risk of aspiration/regurgitation in an emergency. The procedures of classical RSII include effective pre-oxygenation, administration of thiopental and succinylcholine, application of cricoid pressure, avoidance of positive-pressure ventilation before intubation, and intubation with a cuffed tracheal tube. Although RSII has evolved many times, its clinical benefits and risks remain undefined. In particular, some of the traditional concepts of RSII have been changed by the development of pre-oxygenation, visualization of intubation, application of positive-pressure ventilation, and other new techniques. This article reviews the latest progress of RSII research, aiming to provide a better reference for clinical practice. |