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| 围术期神经认知障碍脑源性生物标志物的研究进展 |
| Research progress of brain-derived biomarkers of perioperative neurocognitive disorder |
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| DOI：10.12089/jca.2023.10.014 |
| 中文关键词: 围术期神经认知障碍 生物标志物 谵妄 |
| 英文关键词: Perioperative neurocognitive disorder Biomarkers Delirium |
| 基金项目:国家自然科学基金（82002090） |
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| 中文摘要: |
| 围术期神经认知障碍（PND）是一种常见于老年患者的术后并发症，其特征是患者出现认知功能下降、记忆受损、注意力不能集中等改变。随着老年患者手术数量的持续增长，出现PND的患者数量也将随之上升。PND的危险因素及诱发因素十分复杂，具体机制尚不清楚，且无统一的诊断标准。本文总结近年来各类PND脑源性生物标志物的研究进展，以期为PND的预测和诊断提供参考。 |
| 英文摘要: |
| Perioperative neurocognitive disorder (PND) is a common postoperative complication in elderly patients, which is characterized by cognitive decline, memory impairment, inattention and other changes. With the continuous growth of the number of elderly surgical patients, the number of patients with PND will also increase. Given that the risk factors and predisposing factors for PND are complex, the specific mechanisms are unclear, and there are no uniform diagnostic criteria. This article summarizes the research progress of brain-derived biomarkers of PND in recent years, in order to provide reference basis for the prediction and diagnosis of PND. |
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