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| 复合羟考酮时环泊酚用于无痛人工流产术的半数有效剂量 |
| Median effective dose of ciprofol combined with oxycodone in painless abortion surgery |
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| DOI：10.12089/jca.2023.10.010 |
| 中文关键词: 环泊酚 羟考酮 无痛人工流产术 序贯法 半数有效剂量 |
| 英文关键词: Ciprofol Oxycodone Painless induced abortion Sequential Median effective dose |
| 基金项目:江苏省中医药管理局科技项目（MS2022057） |
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| 中文摘要: |
目的 探讨复合羟考酮时环泊酚用于无痛人工流产术的半数有效剂量（ED50）。
方法 选择择期行无痛人工流产术患者23例，年龄22～40岁，BMI 20～30 kg/m2，ASA Ⅰ或Ⅱ级。麻醉诱导前静脉推注羟考酮0.08 mg/kg，环泊酚剂量采用序贯法。第1例患者环泊酚剂量为0.6 mg/kg，阳性反应定义为术中发生体动反应，若出现阳性反应则升高一个剂量等级，相邻剂量相差为0.05 mg/kg，若出现阴性反应则降低一个剂量等级，直至出现第7个拐点终止研究。计算复合羟考酮时环泊酚用于无痛人工流产术的ED50和95%有效剂量（ED95）及其95%可信区间（CI）。根据术中是否发生体动将患者分为两组：阳性组和阴性组。记录睫毛反射消失时间、手术时间、苏醒时间。记录术中恶心、呕吐、注射痛、呼吸抑制、过敏的发生情况。
结果 复合羟考酮时环泊酚用于无痛人工流产术的ED50为0.469 mg/kg（95%CI 0.453～0.486 mg/kg），ED95为0.542 mg/kg（95%CI 0.519～0.583 mg/kg）。与阴性组比较，阳性组苏醒时间明显延长（P<0.05）。两组无一例出现恶心、呕吐、注射痛、呼吸抑制、过敏等不良反应。
结论 复合羟考酮时环泊酚用于无痛人工流产术的ED50为0.469 mg/kg（95%CI 0.453～0.486 mg/kg），ED95为0.542 mg/kg（95%CI 0.519～0.583 mg/kg）。 |
| 英文摘要: |
Objective To explore the median effective dose (ED50) of ciprofol when combined with oxycodone on painless abortion.
Methods Twenty-three patients who underwent painless abortion surgery on a scheduled basis were selected, aged 22-40 years, BMI 20-30 kg/m2, ASA physical status Ⅰ or Ⅱ. Before anesthesia induction, 0.08 mg/kg of oxycodone was injected intravenously, and the dose of ciprofol was adopted sequential. In the first patient, the dose of ciprofol was 0.6 mg/kg. The positive reaction of painless abortion is defined as a body movement reaction that occurs during the surgical process. If there was a positive reaction, the dose level was increased by one level, and if there was a negative reaction, the dose level was reduced by one level. The difference between adjacent doses was 0.05 mg/kg, the study was terminated until 7 inflection points were found. The ED50, 95% effective dose (ED95) and corresponding 95% confidence interval (CI) of ciprofol combined with oxycodone on painless induced abortion were calculated. The patients were divided into two groups based on whether there was body movement during surgery: positive group and negative group. The time of disappearance of eyelash reflex, end of surgery, awakening time were recorded. The occurrence of intraoperative nausea, vomiting, injection pain, respiratory inhibition, and allergy were recorded.
Results The ED50 of ciprofol for painless abortion was 0.469 mg/kg (95% CI 0.453-0.486 mg/kg), and the ED95 was 0.542 mg/kg (95% CI 0.519-0.583 mg/kg). Compared with negative group, the awakening time of the positive group was significantly prolonged. No adverse reactions such as nausea, vomiting, injection pain, respiratory inhibition, or allergies occurred in either group of patients.
Conclusion When combined with oxycodone, the ED50 of ciprofol for painless abortion is 0.469 mg/kg (95% CI 0.453-0.486 mg/kg), and the ED95 of ciprofol for painless abortion is 0.542 mg/kg (95% CI 0.519-0.583 mg/kg). |
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