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| 围术期神经认知障碍患者远期认知功能下降的研究进展 |
| Research progress on long-term cognitive function decline of perioperative neurocognitive disorder |
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| DOI：10.12089/jca.2023.09.017 |
| 中文关键词: 围术期神经认知障碍 远期认知功能下降 阿尔茨海默病 老年 |
| 英文关键词: Perioperative neurocognitive disorder Long-term cognitive function decline Alzheimer's disease Aged |
| 基金项目:山东省自然科学基金（ZR2021MH168，ZR2020MH391）；山东省医学会临床科研资金（YXH2022ZX02103）;济南市“新高校20条”资助项目科研带头人工作室（202228124）；山东省中医药科技项目（Z-2022048） |
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| 中文摘要: |
| 围术期神经认知障碍（PND）是老年患者围术期常见的并发症之一，表现为围术期注意力不集中、思维逻辑能力下降、学习记忆能力减退，严重影响患者术后康复。近年来，大量研究表明术前已存在或术后早期出现的认知功能损害与术后远期认知功能下降相关，而干预术后早期认知功能改变或可影响术后远期认知发展轨迹，因此探索术后早期认知功能改变的干预方法和相关机制至关重要。本文对PND患者术后12个月后患者认知功能的发展轨迹及影响因素进行综述，以提供干预术后早期认知功能改变的思路或方法。 |
| 英文摘要: |
| Perioperative neurocognitive disorder (PND) is one of the most common perioperative complications in elderly patients, which is characterized by poor concentration, decreased ability of thinking and logic, impairment of learning and memory, and it seriously affects the recovery of post-surgical patients. In recent years, a large number of studies have shown that pre-existing or early postoperative cognitive impairment is associated with long-term postoperative cognitive decline, therefore, it is very important to study and explore the intervention methods and related mechanisms of early postoperative cognitive function changes. In this review, we discuss the development trajectory of cognitive function and its influencing factors 12 months after operation, in order to provide ideas or methods to intervene the cognitive function changes in the early stage after surgery. |
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