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| 环泊酚用于老年患者经内镜逆行胰胆管造影术的效果 |
| Efficacy of ciprofol in elderly patients undergoing endoscopic retrograde cholangiopancreatography |
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| DOI：10.12089/jca.2023.06.010 |
| 中文关键词: 环泊酚 丙泊酚 经内镜逆行胰胆管造影术 老年 注射痛 |
| 英文关键词: Ciprofol Propofol Endoscopic retrograde cholangiopancreatography Aged Injection pain |
| 基金项目:辽宁省民生科技计划项目（2021JH2/10300011） |
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| 中文摘要: |
目的 评价环泊酚用于老年患者经内镜逆行胰胆管造影术（ERCP）麻醉的有效性及安全性。
方法 选择2021年10月至2022年4月择期行ERCP的老年患者284例，男145例，女139例，年龄65～90岁，BMI 18～30 kg/m2，ASA Ⅱ或Ⅲ级。采用随机数字表法将患者分为两组：环泊酚组（C组）与丙泊酚组（P组），每组142例。记录镇静成功例数，入室前（T0）、诱导后（T1）、进镜时（T2）、置入十二指肠乳头时（T3）、退镜时（T4）、苏醒时（T5）的HR、MAP、SpO2。记录镇静诱导成功时间、苏醒时间和离室时间。记录注射痛的发生情况。
结果 两组镇静成功率均为100%。与P组比较，T1—T5时C组HR明显增快，MAP、SpO2明显升高（P<0.05），镇静诱导成功时间明显延长（P<0.05），苏醒时间和离室时间明显缩短（P<0.05），注射痛发生率明显降低（P<0.05）。
结论 丙泊酚与环泊酚均可安全有效用于老年患者ERCP手术麻醉，与丙泊酚比较，采用环泊酚患者苏醒时间、离院时间更短，注射痛发生率更低。 |
| 英文摘要: |
Objective To evaluate the effectiveness and safety of ciprofol for anesthesia in elderly patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).
Methods A total of 284 elderly patients, 145 males and 139 females, aged 65-90 years, BMI 18-30 kg/m2, ASA physical status Ⅱ or Ⅲ were selected for elective ERCP from October 2021 to April 2022. A random number table method was used to divide the patients into two groups: the ciprofol group (group C) and the propofol group (group P), 142 patients in each group. The number of successful cases of anesthesia was recorded. HR, MAP, and SpO2 were recorded when entering the operating room (T0), after induction (T1), at the time of placing the endoscope (T2), at the time of reaching duodenal papilla (T3), at the time of withdrawing the endoscope (T4), and at the time of awakening (T5). The time of successful sedation induction, time of complete awakening, and time of departure from the PACU room were recorded. The occurrences of injection pain was recorded.
Results The sedation success rate was 100% in both groups. Compared with group P, group C had significantly higher HR, MAP, and SpO2 at T1-T5 (P < 0.05), significantly longer successful sedation induction time (P < 0.05), significantly shorter time to complete awakening and time to leave the PACU room (P < 0.05), and significantly lower incidence of injection pain (P < 0.05).
Conclusion Both propofol and cyclopofol can be safely and effectively used for anesthesia in elderly patients with ERCP surgery. Compared with propofol, cyclopofol patients have shorter recovery time, shorter discharge time and lower incidence of injection pain. |
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