文章摘要
环泊酚与丙泊酚用于腹腔镜胆囊切除术全麻诱导与维持的比较
Comparison of ciprofol and propofol on induction and maintenance of general anesthesia in patients undergoing laparoscopic cholecystectomy
  
DOI：10.12089/jca.2023.06.008
中文关键词: 腹腔镜胆囊切除术  全麻诱导与维持  环泊酚  丙泊酚
英文关键词: Laparoscopic cholecystectomy  Induction and maintenance of general anesthesia  Ciprofol  Propofol
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作者单位E-mail
郭顺 434000,湖北省荆州市,长江大学附属第一医院,荆州市第一人民医院麻醉科  
曾晓琴 434000,湖北省荆州市,长江大学附属第一医院,荆州市第一人民医院麻醉科  
李波 434000,湖北省荆州市,长江大学附属第一医院,荆州市第一人民医院麻醉科  
贺彬彬 434000,湖北省荆州市,长江大学附属第一医院,荆州市第一人民医院麻醉科  
夏瑞 434000,湖北省荆州市,长江大学附属第一医院,荆州市第一人民医院麻醉科 879560350@qq.com 
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中文摘要:
      
目的 比较环泊酚和丙泊酚用于腹腔镜胆囊切除术患者全麻诱导与维持的效果。



方法 选择择期行腹腔镜胆囊切除术患者80例，男32例，女48例，年龄18～64岁，BMI 18～30 kg/m2，ASAⅠ或Ⅱ级。采用随机数字表法将患者分为两组：环泊酚组和丙泊酚组，每组40例。环泊酚组、丙泊酚组分别静脉给予环泊酚0.4 mg/kg、丙泊酚2 mg/kg，两组均依次给予舒芬太尼0.5 μg/kg及罗库溴铵0.6 mg/kg行全麻诱导。环泊酚组静脉泵注环泊酚0.8～2.4 mg·kg-1·h-1，丙泊酚组泵注丙泊酚4～12 mg·kg-1·h-1，同时均泵注瑞芬太尼8～15 μg·kg-1·h-1维持麻醉，维持NI值36～64。记录手术时间、诱导时间、苏醒时间、PACU恢复时间，记录诱导前及诱导后1、3 min的HR和MAP。记录注射痛、诱导期呼吸暂停的发生情况。

结果 与丙泊酚组比较，环泊酚组诱导时间明显延长（P＜0.05），环泊酚组诱导后1、3 min HR明显增快，MAP明显升高（P＜0.05），注射痛发生率明显降低（P＜0.05），诱导期呼吸暂停发生率明显降低（P＜0.05）。两组手术时间、苏醒时间、PACU恢复时间差异无统计学意义。

结论 环泊酚与丙泊酚均能有效应用于腹腔镜胆囊切除术患者全麻的诱导与维持，与丙泊酚比较，环泊酚诱导时间延长，但呼吸抑制和注射痛发生率更低。
英文摘要:
      
Objective To compare the effect of ciprofol and propofol on the induction and maintenance of general anaesthesia in patients undergoing laparoscopic cholecystectomy.

Methods Eighty patients undergoing laparoscopic cholecystectomy, 32 males and 48 females, aged 18-64 years, BMI 18-30 kg/m2, ASA physical status Ⅰ or Ⅱ, were randomly divided into two groups: ciprofol group and propofol group, 40 patients in each group. The ciprofol group and propofol group were respectively given ciprofol 0.4 mg/kg and propofol 2.0 mg/kg intravenously. Both groups were then given sufentanil 0.5 μg/kg and rocuronium 0.6 mg/kg for general anaesthesia induction. Ciprofol 0.8-2.4 mg·kg-1·h-1 was pumped intravenously in theciprofol group, and propofol 4.0-12.0 mg·kg-1·h-1 was pumped in thepropofol group, while remifentanil 8.0-15.0 μg·kg-1·h-1 was pumped in both groups to maintain anaesthesia. Maintaining Narcotrend index (NI) values of 36-64. The operation time, induction time, recovery time, and PACU recovery time were recorded. HR and MAP before induction and 1 and 3 minutes after induction were recorded. The injection pain and apnea during induction were recorded.

Results Compared with the propofol group, the incidence of injection pain in the ciprofol group was significantly decreased (P < 0.05), the induction time was significantly extended(P < 0.05), HR and MAP were significantly increased 1 and 3 minutes after induction in the ciprofol group(P < 0.05), and the incidence of apnea during induction was significantly decreased(P < 0.05). There were no significant differences in the operation time, recovery time, and PACU recovery time.

Conclusion Both ciprofol and propofol can be effectively applied to the induction and maintenance of general anesthesia in laparoscopic cholecystectomy patients. Compared with propofol, the induction time of cyclopofol is longer, but the incidence of respiratory depression and injection pain is lower.
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