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| 蒙药额尔敦-乌日勒对老年患者胸科手术后睡眠质量的影响 |
| Effect of Eerdun Wurile on sleep quality of elderly patients after thoracic surgery |
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| DOI：10.12089/jca.2023.05.011 |
| 中文关键词: 额尔敦-乌日勒 老年 胸科手术 术后睡眠质量 褪黑素 |
| 英文关键词: Eerdun Wurile Aged Thoracic surgery Postoperative sleep quality Melatonin |
| 基金项目:内蒙古自治区蒙医药协同创新中心科研项目(MYYXT201902)；内蒙古自然科学基金(2020LH08032)；内蒙古医科大学附属医院博士启动基金项目(NYFY BS202134)；高等学校青年科技英才支持计划项目(NJYT22020) |
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| 中文摘要: |
目的 探讨蒙药额尔敦-乌日勒对老年患者胸科手术后睡眠质量的影响。
方法 选择择期行胸科手术的老年患者60例，男31例，女29例，年龄≥65岁，BMI 18~24 kg/m2，ASA Ⅰ—Ⅲ级。采用随机数字表法将患者分为两组：对照组(C组)和蒙药额尔敦-乌日勒组(E组)，每组30例。C组于术前3 d至术后3 d每日晨起后口服淀粉胶囊；E组在相同时间点口服蒙药额尔敦-乌日勒15粒(每粒2 g)。采用匹兹堡睡眠质量指数量表(PSQI)评估术前3 d和术后1个月患者夜间睡眠质量。采用理查兹-坎贝尔睡眠量表(RCSQ)评估术前3 d和术后第1天夜间睡眠质量。采用ELISA法检测术前3 d服药前、术后第1、4天血浆褪黑素(MT)、γ-氨基丁酸(GABA)和肿瘤坏死因子-α(TNF-α)浓度。采用术后恢复质量量表(QoR-40)评估患者恢复质量。
结果 与C组比较，E组术后1个月PSQI量表评分明显降低，术后第1天RCSQ量表评分明显增高(P＜0.05)，术后第1、4天MT浓度和GABA浓度明显升高，TNF-α浓度明显降低(P＜0.05)，术后第1天情绪状态、身体舒适度、自理能力和总分明显升高(P＜0.05)。
结论 围术期服用蒙药额尔敦-乌日勒有助于改善患者术后睡眠质量，促进患者术后快速康复。 |
| 英文摘要: |
Objective To investigate the effect of Eerdun Wurile, a Mongolian drug, on sleep quality in elderly patients after thoracic surgery.
Methods Sixty elderly patients undergoing elective thoracic surgery, 31 males and 29 females, aged ≥ 65 years, BMI 18-24 kg/m2, ASA physical status Ⅰ-Ⅲ, were randomly divided into two groups: control group (group C) and Eerdun Wurile group (group E), 30 patients in each group. In group C, starch capsules were taken orally every morning from 3 days before surgery to 3 days after surgery. Group E was treated with 15 tablets of Eerdun Wurile (2 g per capsule) at the same time. The patients' sleep quality was assessed with the Pittsburgh sleep quality index (PSQI) 3 days before surgery and 1 month after surgery. The Richards-Campbell sleep scale (RCSQ) was used to assess the quality of night sleep 3 days before surgery and 1st day after surgery. The plasma melatonin (MT), γ-aminobutyric acid (GABA) and tumor necrosis factor-α (TNF-α) concentrations before taking medicine 3 days before surgery, on the 1st day and 4th day after surgery were measured by ELISA. And the quality of postoperative recovery scale (QoR-40) was used to assess the quality of recovery.
Results Compared with group C, PSQI score was significantly decreased in group E 1 month after surgery and RCSQ score was significantly increased on the 1st day after surgery (P < 0.05). Compared with group C, the MT and GABA concentrations in group E were significantly increased on the 1st and 4th day after operation, and the TNF-α concentration was significantly decreased on the 1st and 4th day after surgery (P < 0.05). Compared with group C, the emotional state, physical comfort, self-care ability and total score of patients in group E were increased significantly on the 1st day after surgery (P < 0.05).
Conclusion Perioperative administration of Mongolian drug Eerdun Wurile improves the postoperative sleep quality and promote rapid recovery. |
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