文章摘要
烟酰胺腺嘌呤二核苷酸在昼夜节律紊乱中的研究进展
Research progress on nicotinamide adenine dinucleotide in the circadian rhythm disruption
  
DOI：10.12089/jca.2023.02.014
中文关键词: 烟酰胺腺嘌呤二核苷酸  聚腺苷二磷酸-核糖聚合酶  昼夜节律
英文关键词: Nicotinamide adenine dinucleotide  Polyadenosine diphosphate-ribose polymerase  Circadian rhythm
基金项目:国家自然科学基金（81730033）
作者单位E-mail
刘帅 210008,南京医科大学鼓楼临床医学院  
彭良玉 南京大学医学院附属鼓楼医院麻醉科  
许继岩 南京大学医学院附属鼓楼医院麻醉科  
夏天娇 南京大学分子医学江苏重点实验室  
顾小萍 210008,南京医科大学鼓楼临床医学院 xiaopinggu@nju.edu.cn 
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中文摘要:
      昼夜节律紊乱在衰老、神经退行性病变、糖尿病和肿瘤的发生过程中起着重要的作用。烟酰胺腺嘌呤二核苷酸（NAD+）的表达及合成NAD+相关的关键酶具有明显的昼夜节律，昼夜节律受到NAD+的调控，NAD+表达减少可导致昼夜节律明显紊乱。补充NAD+的前体物质或者促进NAD+生成在缓解昼夜节律紊乱的同时可以明显缓解衰老、神经退行性病变、糖尿病和肿瘤的发生。
英文摘要:
      Circadian rhythm disruption plays an important role in aging, neurodegeneration, diabetes and the development of tumors. The expression of nicotinamide adenine dinucleotide (NAD+) and the key enzymes related to the synthesis of NAD+ have remarkable circadian rhythm, which in turn is regulated by NAD+. Decreased NAD+ expression can lead to significant circadian disruption. Supplementing the precursor of NAD+ or promoting the generation of NAD+ can significantly relieve aging, neurodegeneration, diabetes and the occurrence of tumors while alleviating circadian rhythm disorders.
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