文章摘要
围术期电针干预对术后谵妄影响的Meta分析
Effect of perioperative electroacupuncture intervention on postoperative delirium: a meta-analysis
  
DOI：10.12089/jca.2023.01.013
中文关键词: 电针  术后谵妄  系统评价  Meta分析
英文关键词: Electroacupuncture  Postoperative delirium  Systematic reviews  Meta-analysis
基金项目:北京市“首都特色”科技计划课题（Z171100001017061）；首都中医药研究专项重点课题（17ZY04）；北京市属医院科研培育计划项目（PZ2017028）
作者单位E-mail
罗见生 100010,首都医科大学附属北京中医医院麻醉科  
宁甲齐 100010,首都医科大学附属北京中医医院麻醉科  
丁玲玲 100010,首都医科大学附属北京中医医院麻醉科 dinglingling301@126.com 
陈卓娅 100010,首都医科大学附属北京中医医院麻醉科  
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中文摘要:
      
目的 系统评价围术期电针干预对全麻手术患者术后谵妄（POD）的影响。
方法 计算机检索PubMed、Embase、Cochrane、中国知网、万方和中国生物医学文献数据库（CBM），收集电针干预对全麻手术患者POD的随机对照试验（RCT），检索时间为建库至2022年3月。采用RevMan 53软件进行Meta分析。
结果 共纳入11篇RCT研究，共计患者924例，电针组463例，对照组461例。与对照组比较，电针组POD发生率明显降低（RR=0.44，95%CI 0.35～0.54，P＜0.001），术后1 d血清S100β蛋白（SMD=-1.83，95%CI -2.66～-1.01，P＜0.001）和神经元特异性烯醇化酶（NSE）浓度（MD=-3.85 ng/ml，95%CI -4.39～-3.31 ng/ml，P＜0.001）明显降低。
结论 围术期使用电针可降低患者POD的发生率、降低患者术后1 d血清S100β蛋白和NSE浓度。
英文摘要:
      
Objective To systematically evaluate the effectiveness of perioperative electroacupuncture intervention on postoperative delirium (POD) in patients undergoing general anesthesia.
Methods The articles of randomized controlled trials (RCTs) of electroacupuncture treatment for postoperative delirium were retrieved from the following databases from the time of database establishment to March 2022, PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), Wanfang database, and China Biomedical Literature Database (CBM). RevMan 5.3 software was used for meta-analysis.
Results A total of 11 RCTs with 924 patients were included, 463 patients in electroacupuncture group, 461 patients in the control group. Compared with the control group, the incidence of POD in the electroacupuncture group was significantly lower (RR = 0.44, 95% CI 0.35 to 0.54, P < 0.001), and the concentrations of the serum S100β protein (SMD = -1.83, 95% CI -2.66 to -1.01, P < 0.001) and neuron-specific enolase (NSE) (MD = -3.85 ng/ml, 95% CI -4.39 to -3.31 ng/ml, P < 0.001) were significantly reduced on the 1st day after surgery.
Conclusion Perioperative electroacupuncture intervention can reduce the incidence of POD, serum S100β protein and NSE concentrations on the first day after surgery.
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