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| 环泊酚与丙泊酚在老年患者无痛胃镜检查中的比较 |
| Comparison of ciprofol and propofol in elderly patients undergoing gastroscopy |
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| DOI：10.12089/jca.2022.07.008 |
| 中文关键词: 环泊酚 丙泊酚 无痛胃镜 老年 |
| 英文关键词: Ciprofol Propofol Painless gastroscopy Aged |
| 基金项目:贵州省科学技术基金（2021XMSB00032352）；康盟基金会-医学与健康事业研究发展基金项目（S014B） |
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| 中文摘要: |
目的 观察和比较环泊酚和丙泊酚在老年患者无痛胃镜检查中的效果。
方法 选择行无痛胃镜检查老年患者159例，男83例，女76例，年龄65～75岁，BMI 18～30 kg/m 2，ASA Ⅰ或Ⅱ级。将患者随机分为两组：丙泊酚1 mg/kg组（P组，n=80）和环泊酚0.2 mg/kg组（C组，n=79）。所有患者静注舒芬太尼0.1 μg/kg，30 s后P组给予丙泊酚1 mg/kg、C组给予环泊酚0.2 mg/kg，待改良警觉/镇静评分（MOAA/S）≤1分即开始胃镜检查。记录镇静成功例数、诱导时间、苏醒时间、离院时间。记录心动过缓、低血压、呼吸抑制、注射痛、呛咳、体动、恶心呕吐等不良反应的发生情况。检查结束后，评估麻醉科医师、内镜医师和患者满意情况。
结果 两组镇静成功率、诱导时间和苏醒时间差异无统计学意义。C组离院时间明显长于P组（P＜0.05），低血压、呼吸抑制、注射痛发生率明显低于P组（P＜0.05），麻醉科医师满意率明显高于P组（P＜0.05）。两组心动过缓、呛咳、体动、恶心呕吐等不良反应发生率差异无统计学意义。两组内镜医师和患者满意率差异无统计学意义。
结论 环泊酚0.2 mg/kg在老年患者胃镜检查中能提供和丙泊酚1 mg/kg相似的镇静效果，诱导时间和苏醒时间相当，低血压、呼吸抑制及注射痛等不良反应少，值得临床推广。 |
| 英文摘要: |
Objective To observe the effect of ciprofol and propofol in painless gastroscopy in elderly patients.
Methods A total of 159 elderly patients underwent painless gastroscopy,83 males and 76 females,aged 65-75 years,BMI 18-30 kg/m 2,ASA physical status Ⅰ or Ⅱ,were randomly divided into two groups: propofol 1 mg/kg (group P, n = 80) and ciprofol 0.2 mg/kg (group C, n = 79). All patients were given sufentanil 0.1 μg/kg, and group P was given propofol 1 mg/kg, group C was given ciprofol 0.2 mg/kg after 30 seconds. Gastroscopy was performed when the modified observer's assessment of alertness/sedation (MOAA/S)score ≤ 1. The success cases of sedation, the time of induction and awakening and the time of discharge were recorded. The adverse reactions such as decreased heart rate, hypotension, respiratory depression, injection pain, cough, body movement, nausea and vomiting were also recorded. At the end of the examination, the satisfaction of anesthesiologists, physicians and patients were evaluated.
Results There were no significant differences in sedation success rate, induction time and recovery time between the two groups. The time of hospitalization in group C was significantly longer than that in group P, and the incidence of hypotension, respiratory depression and injection pain was significantly lower than that in group P (P < 0.05). The satisfaction rate of anesthesiologists in group C was significantly higher than that in group P (P < 0.05). There were no significant differences in the incidence of decreased heart rate, cough, body movement, nausea and vomiting between the two groups. There were no significant differences in the satisfaction rate of physicians and patients between the two groups.
Conclusion Ciprofol 0.2 mg/kg can provide a sedative effect similar to that of propofol 1 mg/kg in gastroscopy in elderly patients,with similar induction time and recovery time,and less adverse reactions,such as hypotension,respiratory depression and injection pain,which is worthy of clinical promotion. |
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