|
| 右美托咪定经鼻喷雾治疗术后睡眠障碍的效果 |
| Efficacy of dexmedetomidine nasal spray for postoperative sleep disorders |
| |
| DOI：10.12089/jca.2022.05.006 |
| 中文关键词: 右美托咪定 经鼻喷雾 术后睡眠障碍 多导睡眠监测 颌面外科 |
| 英文关键词: Dexmedetomidine Nasal spray Postoperative sleep disorders Polysomnography Maxillofacial surgery |
| 基金项目: |
| 作者 | 单位 | E-mail | | 王烨 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | | | 郅娟 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | | | 邓晓明 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | dengxiaoming2003@sina.com | | 相贵华 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | | | 靳紫彬 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | | | 陈柯宇 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | | | 徐文莉 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | | | 杨冬 | 100144,中国医学科学院,北京协和医学院整形外科医院麻醉科 | |
|
| 摘要点击次数: 1984 |
| 全文下载次数: 541 |
| 中文摘要: |
目的 观察右美托咪定经鼻喷雾治疗术后睡眠障碍的临床效果。
方法 选择全麻气管插管下行颌面外科手术患者78例，男12例，女66例，年龄18～40岁，ASAⅠ或Ⅱ级。将患者随机分为两组：对照组（C组）和右美托咪定组（D组），每组39例。术后当天21:30 C组和D组分别给予生理盐水0.01 ml/kg和右美托咪定1 μg/kg经鼻喷雾。采用多导睡眠监测仪（PSG）记录术后当天N1期、N2期、N3期、REM期睡眠时间、清醒时间、觉醒次数和睡眠效率。采用匹兹堡睡眠质量指数（PSQI）量表评估术前1个月及术后当天的睡眠情况。记录术后当天补救镇静镇痛情况。
结果 与C组比较，术后当天D组N2期睡眠明显延长（P＜0.05），清醒时间明显缩短（P＜0.05），觉醒次数明显减少（P＜0.05），睡眠效率明显提高（P＜0.05）。与术前1个月比较，术后当天两组PSQI总分明显升高（P＜0.05），与C组比较，术后当天D组PSQI总分明显降低（P<0.05）。术后当天两组补救镇静镇痛率差异无统计学意义。
结论 通过右美托咪定经鼻喷雾，可有效延长颌面外科手术患者术后当天的N2期睡眠，缩短清醒时间，减少觉醒次数，明显提高睡眠效率。 |
| 英文摘要: |
Objective To explore the clinical effect of dexmedetomidine nasal spray in the treatment of postoperative sleep disorders.
Methods Seventy-eight patients underwent maxillofacial surgery under general anesthesia tracheal intubation were enrolled, 12 males and 66 females, aged 18-40 years, ASA physical status Ⅰ or Ⅱ. The patients were randomly divided into two groups: control group (group C) and dexmedetomidine group (group D), 39 patients in each group. At 21:30 on the day after surgery, group C and group D were respectively given normal saline 0.01 ml/kg and dexmedetomidine 1 μg/kg using drug atomized nasal spray. Polysomnography (PSG) recorded sleep condition on the day after surgery. The sleep time of N1, N2, N3, and REM, waking time, number of awakenings, and sleep efficiency were recorded. The Pittsburgh sleep quality index (PSQI) assessed the patient＇s sleep quality of baseline and the day after surgery. The use of rescue sedative and analgesic drugs on the day after the surgery were recorded.
Results Compared with group C on the day after surgery, the sleep time of N2 were significantly prolonged (P < 0.05), waking time were significantly shortened (P < 0.05), number of awakenings were significantly decreased (P < 0.05), sleep efficiency were significantly improved (P < 0.05). Compared with 1 month before surgery, the PSQI scores of the two groups on the day after surgery were significantly increased (P < 0.05). On the day after surgery, the PSQI score of group D was significantly lower than that of group C (P < 0.05). There were no significant differences in the rate of postoperative sedation and analgesia between the two groups.
Conclusion Dexmedetomidine nasal spray can safely and effectively improve the quality and efficiency of sleep on the day after maxillofacial surgery. The nasal spray of dexmedetomidine can prolong the N2 sleep time of the first day of patients undergoing maxillofacial surgery, shorten the waking time, reduce the number of wakes, and significantly improve the sleep efficiency. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
