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| 阻塞性睡眠呼吸暂停对认知功能影响的研究进展 |
| Research progress on the effect of obstructive sleep apnea on cognitive fuction |
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| DOI：10.12089/jca.2022.04.020 |
| 中文关键词: 阻塞性睡眠呼吸暂停 认知功能 慢性缺氧 |
| 英文关键词: Obstructive sleep apnea Cognitive function Chronic hypoxia |
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| 中文摘要: |
| 阻塞性睡眠呼吸暂停是上呼吸道阻塞引起的憋醒、打鼾，并伴有呼吸表浅和呼吸暂停等的一种临床症状，可致慢性缺氧、局部和全身炎症反应增加及内皮功能障碍、激活交感神经活性、间歇性低氧血症和高碳酸血症。近年来，认知功能损害已被证实是阻塞性睡眠呼吸暂停的一个不可忽视的重要并发症。本文回顾了近几年有关阻塞性睡眠呼吸暂停与认知功能损害之间相关性的文献，从阻塞性睡眠呼吸暂停与认知功能的特征、阻塞性睡眠呼吸暂停及认知功能损害相关性、阻塞性睡眠呼吸暂停损害认知的病理机制等方面作一综述。 |
| 英文摘要: |
| Obstructive sleep apnea (OSA) is caused by obstruction of the upper airway, resulting in awakening, snoring with superficial breathing and apnea. OSA can lead to chronic hypoxia, local and systemic inflammatory responses, endothelial dysfunction, activate sympathetic nerve activity, intermittent hypoxemia and hypercapnia. Cognitive impairment has been found to be an important complication of OSA in recent years. The article reviews the literature on the correlation between OSA and cognitive impairment in recent years, and provides a review of the characteristics of OSA and cognitive function, the relationship between OSA and cognitive impairment, and the mechanism of OSA impairing cognitive function. |
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