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| 新鲜冰冻血浆在危重症患者中应用的进展 |
| Progress in the application of fresh frozen plasma in critically ill |
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| DOI：10.12089/jca.2022.03.019 |
| 中文关键词: 新鲜冰冻血浆 危重症 不良反应 |
| 英文关键词: Fresh frozen plasma Critically ill Adverse reactions |
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| 中文摘要: |
| 伴随着大力倡导成分输血，新鲜冰冻血浆（FFP）的需求日益增多。FFP是补充血容量、纠正患者凝血状态、改善血管内皮的重要物质，在危重症患者中的应用尤为广泛。大约50%左右的FFP在凝血障碍的危重症患者中预防性使用。在有创操作前预防性使用FFP的作用有限，不仅没有降低患者术后出血的风险，而且增加了术后急性肺损伤的发生。对于脓毒症、失血性休克等危重症患者，尽早应用FFP进行液体复苏，能显著改善患者的预后，降低患者的死亡率。全文拟从FFP在危重症患者中的应用、目前临床应用存在的问题，以及可能引起的不良反应等内容作一总结，以期为临床中FFP的合理使用提供参考。 |
| 英文摘要: |
| With the vigorous promotion of component blood transfusion in the clinic, the demand for fresh frozen plasma (FFP) is increasing. FFP is important to expand blood volume, correct the blood coagulation state of patients and improve vascular endothelium. It is particularly widely used in critically ill patients. About half of FFP is used prophylactically in critically ill patients with coagulopathy. Studies have shown that preventive use of FFP before invasive procedures has limited effects, it not only does not reduce the risk of postoperative bleeding in patients, but also increases the incidence of postoperative acute lung injury. However, it can significantly improve the prognosis of patients and reduce the rate of mortality to use FFP for fluid resuscitation as soon as possible if patients combined with sepsis and hemorrhagic shock. This review intends to summarize the applications of FFP in critically ill patients, the problems in clinical applications and possible adverse reactions caused by transfusing FFP, which hopefully will provide a theoretical reference for the rational use of FFP in clinical practice. |
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