| Astrocytes are the largest number of cells in the central nervous system. Under physiological conditions, astrocytes mainly provide energy and nutritional support for neurons, affect synaptic formation and synaptic plasticity, participate in neurotransmitter metabolism and blood-brain barrier formation, and affect the permeability of blood-brain barrier. Under surgical and anesthetic stress, astrocytes are overactivated, mediating neuroinflammatory processes, affecting neuronal energy supply and transmitter metabolism, leading to abnormal synaptic plasticity, blood-brain barrier disruption, and increased permeability, which in turn leads to perioperative neurocognitive dysfunction． |
