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| 神经炎症对术后认知功能障碍影响的研究进展 |
| Adcances in effect of neuroinflammation on postoperative cognitive dysfunction |
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| DOI：10.12089/jca.2021.12.020 |
| 中文关键词: 认知障碍 麻醉 神经炎症 老年 |
| 英文关键词: Cognitive impairment Anesthesia Neuroinflammation Aged |
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| 中文摘要: |
| 术后认知功能障碍（POCD）是手术和麻醉后的常见并发症，老年患者预后较差。POCD表现为注意力、意识、知觉和判断力下降，并时常伴随情绪和人格行为的异常改变，对患者和其家庭有较大的社会和经济影响。POCD相关机制包括中枢神经炎症和外周炎性因子的共同作用，其中神经炎症在POCD的病理生理发展过程中十分重要，然而神经炎症参与POCD发生与发展的机制尚不明确。本文章就神经炎症及其相关研究机制与POCD的关系做一综述，以期为探究POCD的发病机制和寻找新的潜在靶点提供新思路。 |
| 英文摘要: |
| Postoperative cognitive dysfunction (POCD) is a common complication after surgery and anesthesia, with poor prognosis, especially in elderly patients with POCD related performances as decreased attention, consciousness and judgment, and often accompanied by abnormal changes in mood and personality behavior, which has a greater social and economic impact on patients and their families. The related mechanisms of POCD include the co-action of central neuroinflammation and peripheral inflammatory factors, among which neuroinflammation plays an important role in the pathophysiological development of POCD. However, how neuroinflammation is involved in the occurrence and development of POCD, has not been fully clarified. This review summarizes the effects of neuroinflammation and its related research mechanisms on POCD, in order to provide new ideas for exploring the pathogenesis of POCD and finding new potential targets. |
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