文章摘要
心脏外科术后肺部并发症的危险因素
Risk factors of postoperative pulmonary complications of cardiac surgery
  
DOI:10.12089/jca.2021.10.003
中文关键词: 术后肺部并发症  心房颤动  心脏手术  危险因素
英文关键词: Postoperative pulmonary complications  Atrial fibrillation  Cardiac surgery  Risk factors
基金项目:安徽省转化医学研究院科研基金(2020zhyx-A06);安徽医科大学科研平台基地建设提升计划资助项目(2020xkjT060)
作者单位E-mail
施舟 230601,合肥市,安徽医科大学第二附属医院麻醉与围术期医学科  
陈振星 安徽普通高校重点实验室  
王斌 安徽普通高校重点实验室  
张野 230601,合肥市,安徽医科大学第二附属医院麻醉与围术期医学科 zhangye_hassan@sina.com 
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中文摘要:
      
目的 分析心脏外科术后肺部并发症(PPCs)的危险因素。
方法 回顾性分析2017年1月至2020年12月行心脏外科手术患者的病历资料,根据患者是否发生PPCs分为两组:并发症组(n=271)和无并发症组(n=331)。提取性别、年龄、ASA分级、高血压病史、糖尿病病史、慢性阻塞性肺疾病(COPD)病史、脑血管病史、手术史、术前房颤、肺动脉高压、心功能指标、凝血功能指标、肝肾功能指标、乳酸脱氢酶、血糖、手术时间、心肺转流(CPB)时间、术中药物使用情况、术中输血量、术中液体输注量、术中尿量、术后肝肾功能指标、心电图等临床指标,采用单因素分析评估上述指标与PPCs的相关性。将组间差异有统计学意义的单因素纳入Logistic回归模型,分析心脏外科PPCs的独立危险因素。
结果 与无并发症组比较,并发症组年龄、左心房直径明显增大,ASA分级、糖尿病和术前房颤比例、肺动脉高压分级、淋巴细胞含量、尿素氮、球蛋白、总蛋白、乳酸脱氢酶、AST浓度明显升高(P<0.05);手术时间和CPB时间明显延长,术中输注血小板比例明显升高,晶体液输注量明显增多(P<0.05);术后尿素氮、肌酐浓度明显升高,引流量明显增多(P<0.05)。多因素Logistic回归分析结果显示,ASA Ⅳ级(OR=1.886,95%CI 1.030~3.456,P=0.040)、术前房颤(OR=1.526,95%CI 1.031~2.257,P=0.034)、CPB时间≥2 h(OR=2.418,95%CI 1.692~3.456,P<0.001)是心脏外科PPCs的独立危险因素。
结论 术前房颤、ASA Ⅳ级、CPB时间≥2 h是心脏外科PPCs发生的独立危险因素。
英文摘要:
      
Objective To investigate the risk factors of postoperative pulmonary complications of cardiac surgery.
Methods The medical records of patients who underwent cardiac surgery from January 2017 to December 2020 were retrospectively analyzed, while all patients were followed up for occurrence of pulmonary complications after surgery, who were divided into complication group (n = 271) and non-complication group (n = 331). Clinical variables including gender, age, ASA physical status, hypertension history, diabetes history, chronic obstructive pulmonary disease history, cerebrovascular disease history, operation history, preoperative atrial fibrillation, pulmonary hypertension, cardiac function, coagulation function, liver and kidney function, lactate dehydrogenase, blood glucose, operation time, cardiopulmonary bypass time, intraoperative drug use, intraoperative blood transfusion, intraoperative fluid transfusion, intraoperative urine volume, postoperative liver and kidney function, ECG were collected and their correlation with postoperative pulmonary complications were analyzed. Logistic regression was used to screen clinical indicators.
Results Compared with the non-complication group, the patients in the complication group were significantly older, and had a higher value of ASA physical status, preoperative atrial fibrillation and diabetes proportion, left atrial diameter, pulmonary hypertension, lymphocyte, globulin, total protein, lactate dehydrogenase, aspartate aminotransferase, urea nitrogen, operation time, cardiopulmonary bypass time, platelet transfusion, crystalloid fluid volume, postoperative urea nitrogen, postoperative creatinine, and drainage volume (P < 0.05). Multivariate logistic regression analysis suggested that preoperative atrial fibrillation (OR = 1.526, 95% CI 1.031-2.257, P = 0.034), ASA physical status Ⅳ (OR = 1.886, 95% CI 1.030-3.456, P = 0.040), cardiopulmonary bypass duration (OR = 2.418, 95% CI 1.692-3.456, P < 0.001) were independent risk factors.
Conclusion Preoperative atrial fibrillation, ASA physical status Ⅳ, cardiopulmonary bypass duration are independent risk factors of postoperative pulmonary complications of cardiac surgery.
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