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| 瑞马唑仑复合瑞芬太尼用于无痛胃镜检查的半数有效剂量 |
| Median effective dose of remimazolam combined with remifentanil used in painless gastroscope and Clinical validation |
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| DOI：10.12089/jca.2021.09.012 |
| 中文关键词: 瑞马唑仑 瑞芬太尼 无痛胃镜 半数有效剂量 |
| 英文关键词: Remimazolam Remifentanil Painless gastroscopy Median effective dose |
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| 中文摘要: |
目的 测定瑞马唑仑复合瑞芬太尼用于无痛胃镜检查时的半数有效剂量(ED50)及95%有效剂量(ED95)。
方法 本研究共纳入患者73例,分为三组：第一组纳入患者性别不限(n=22),第二组仅纳入男性患者(n=29),第三组仅纳入女性患者(n=22)。根据Dixon改良序贯法,所有患者缓慢静注瑞芬太尼0.5 μg/kg,随后注射瑞马唑仑0.2 mg/kg,待睫毛反射消失后行胃镜检查。若在进镜时及检查过程中出现呛咳、吞咽、皱眉、体动影响检查操作等反应为阳性反应,下一例患者增加0.05 mg/kg,否则降低0.05 mg/kg,以阳性反应转为阴性反应为交叉点,当出现七个交叉点时终止研究。采用概率单位Probit回归分析法计算第一组瑞马唑仑的ED50和ED95及其95%CI,并分别测定第二组、第三组瑞马唑仑的ED50及其95%CI。
结果 第一组瑞马唑仑ED50为0.19 mg/kg(95%CI 0.155~0.229 mg/kg),ED95为0.31 mg/kg(95%CI 0.248~0.492 mg/kg)。第二组瑞马唑仑ED50为0.161 mg/kg (95%CI 0.135~0.192 mg/kg),第三组瑞马唑仑ED50为0.194 mg/kg (95%CI 0.159~0.235 mg/kg)。
结论 瑞马唑仑复合瑞芬太尼用于无痛胃镜检查的ED50、ED95分别为0.19 mg/kg和0.31 mg/kg,且男性患者瑞马唑仑ED50低于女性患者。 |
| 英文摘要: |
Objective To determine the 50% effective dose (ED50) and 95% effective dose (ED95) of remazolam combined with remifentanil in painless gastroscopy.
Methods Seventy-three patients were selected to receive painless gastroscopy and were divided into 3 groups: the first group had no limit to the gender (n = 22), the second group only included males (n = 29), and the third group only included females (n = 22). According to up-and-down method,they were slowly injected remifentanil 0.5 μg/kg in advance, then remimazolam 0.2 mg/kg, and gastroscopy was performed after the eyelash reflex disappeared. The standard for a positive response in patients undergoing gastroscopy: coughing, swallowing, frowning, and physical movement affecting the operation during the examination. The next patient would be increased remimazolam 0.05 mg/kg if there is a positive standrd, otherwise it would be decreased 0.05 mg/kg. And the study was terminated when seven crossing points occurred. Probit regression analysis method was used to calculate the ED50, ED95 and corresponding 95% CI of remimazolam in the first group. The same method was used to calculate the ED50 and 95% CI of remimazolam in the second group and the third group.
Results The ED50 of remimazolam was 0.19 mg/kg and 95% CI was 0.155-0.229 mg/kg, the ED95 was 0.31 mg/kg and 95% CI was 0.248-0.492 mg/kg in the first group. The ED50 of remimazolam in the second group was 0.161 mg/kg and 95% CI was 0.135-0.192 mg/kg. The ED50 of remimazolam in the third group was 0.194 mg/kg and 95% CI was 0.159-0.235 mg/kg.
Conclusion The ED50 and ED95 of remimazolam combined with remifentanil for painless gastroscopy respectively are 0.19 mg/kg and 0.31 mg/kg. The ED50 value of male patients is lower than that of female patients. |
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