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| Homer1a在睡眠剥夺损伤学习和记忆功能中的研究进展 |
| Research progress of Homer1a in learning and memory impairment induced by sleep deprivation |
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| DOI：10.12089/jca.2021.08.024 |
| 中文关键词: Homer1a 睡眠剥夺 学习记忆 突触稳态 |
| 英文关键词: Homer1a Sleep deprivation Learning and memory Synaptic homeostasis |
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| 摘要点击次数: 1980 |
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| 中文摘要: |
| 睡眠是支持学习和记忆等认知功能的重要过程，其中突触功能的调控可能扮演着“开关”角色。睡眠剥夺通过多种途径和机制影响学习记忆功能，其中Homer1a驱动突触稳态的“缩小”调节成为研究的热点。本文围绕睡眠剥夺中Homer1a的表达、Homer1a-mGluR1/5信号途径的作用以及对学习记忆的影响和机制进行阐述，为睡眠剥夺与学习记忆的研究提供一个新思路。 |
| 英文摘要: |
| Sleep is an important process to support cognitive functions such as learning and memory, in which synaptic function regulation may play a “switch” role. Sleep deprivation affects learning and memory function through a variety of pathways and mechanisms, among which Homer1a driving “scaling-down” of synaptic homeostasis has become a hot topic.This review focuses on the expression of Homer1a in sleep deprivation, the role of Homer1a-mGluR1/5 signaling pathway and the influence and mechanism of homer1a on learning and memory, which provides a new idea for the association of sleep deprivation with learning and memory. |
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