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| NLRP3炎性小体与慢性疼痛 |
| NLRP3 inflammasomes and chronic pain |
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| DOI：10.12089/jca.2021.07.023 |
| 中文关键词: NLRP3炎性小体 慢性疼痛 白细胞介素-1β 白细胞介素-18 |
| 英文关键词: NLRP3 inflammasomes Chronic pain Interleukin-1beta Interleukin-18 |
| 基金项目: |
| 作者 | 单位 | E-mail | | 赵庆祥 | 256603,山东省滨州市,滨州医学院附属医院疼痛科 | | | 吴小娟 | 256603,山东省滨州市,滨州医学院附属医院数据统计中心 | wht_159@163.com | | 高勇 | 256603,山东省滨州市,滨州医学院附属医院疼痛科 | | | 林峰 | 256603,山东省滨州市,滨州医学院附属医院麻醉科 | | | 商青青 | 256603,山东省滨州市,滨州医学院附属医院疼痛科 | |
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| 中文摘要: |
| 慢性疼痛是一类机制复杂的疾病，神经炎症被广泛认为是一种重要的促进机制。而NLRP3炎性小体是模式识别受体激活后形成的一种多蛋白复合体，在接收到外源性和内源性信号后，能促进炎性细胞因子的产生，继而引发神经炎症。众多证据表明，NLRP3炎性小体介导的神经炎症在慢性疼痛的发生发展中起着重要作用，靶向NLRP3可能是一种新颖而有效的慢性疼痛治疗策略，是近年来研究的热点之一。基于上述背景，本文综述了NLRP3炎性小体在慢性疼痛中作用的最新进展。 |
| 英文摘要: |
| Chronic pain is a series of disease with complex mechanism, and neuroinflammation was widely considered as a vital mechanism. NLRP3 inflammasomes are multiprotein complex formed from the activation of pattern recognition receptors. After receiving exogenous and endogenous noxious signals, they could facilitate the production of inflammatory cytokines and trigger neuroinflammation. the emerging researches have displayed that NLRP3 inflammasomes mediated neuroinflammation played a critical role in the development and formation of chronic pain, so targeting NLRP3 inflammasomes may be a novel and effective strategy for the treatment of chronic pain, which has been a hotspot in recent years. This review presents a narrative overview of the current understanding of the role of NLRP3 inflammasomes in chronic pain. |
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