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| 纳布啡与舒芬太尼在后腹膜镜术后镇痛效果的比较 |
| Comparison of analgesic effects of nabufen and sufentanil after retroperitoneoscopic surgery |
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| DOI：10.12089/jca.2019.12.008 |
| 中文关键词: 纳布啡 舒芬太尼 术后镇痛 后腹膜镜手术 |
| 英文关键词: Nabuphine Sufentanil Postoperative analgesia Retroperitoneal endoscopic surgery |
| 基金项目:温州市医药卫生科学研究项目计划(2018B53) |
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| 中文摘要: |
目的 观察和比较纳布啡和舒芬太尼在后腹膜镜下肾囊肿去顶术后镇痛中的临床效果。
方法 选择全身麻醉下后腹膜镜手术患者60例,男38例,女22例,年龄55～78岁,BMI 18～25 kg/m2,ASA Ⅰ或Ⅱ级，采用随机数字表法将患者分为两组,每组30例。术后所有患者均行PCIA,其中,纳布啡组镇痛药配方为纳布啡100 mg+托烷司琼10 mg;舒芬太尼组为舒芬太尼100 μg+托烷司琼10 mg;均用生理盐水稀释至100 ml,背景输注速度2 ml/h,单次剂量1 ml,锁定时间15 min。记录给药后2、4、8、16、32 h和48 h的VAS疼痛评分和Ramsay镇静评分,镇痛泵按压次数,镇痛满意率以及术后不良反应发生情况。
结果 两组VAS疼痛评分、镇痛泵按压次数差异无统计学意义。与舒芬太尼组比较,给药后8～48 h纳布啡组Ramsay镇静评分明显升高(P<0.05),镇痛效果满意率明显提高(P<0.05)。纳布啡组恶心呕吐发生率明显低于舒芬太尼组(P<0.01)。两组低血压和心动过缓的发生率差异无统计学意义。
结论 纳布啡用于后腹膜镜术后静脉镇痛效果与舒芬太尼相当,但不良反应更少,患者满意度更高。 |
| 英文摘要: |
Ojective To investigate the clinical effect of nabufen or sufentanil on analgesia after renal cyst unroofing under retroperitoneoscope.
Methods Sixty patients, 38 males and 22 females, aged 55-78 years, BMI 18-25 kg/m2, ASA physical status Ⅰ-Ⅱ, undergoing retroperitoneal laparoscopic surgery under general anesthesia were selected. The patients were divided into two groups by random number table, 30 cases in each group. PCIA was performed in all patients after operation. The analgesic formulation of nabufen group was 100 mg + tropisetron 10 mg; sufentanil group was 100 mg + tropisetron 10 mg; all were diluted with normal saline to 100 ml, background infusion rate was 2 ml/h, single dose was 1 ml, locking time was 15 min. VAS pain score and Ramsay sedation score were recorded 2, 4, 8, 16, 32 and 48 h after administration. Pressure times of analgesic pump, patients satisfaction and occurrence of adverse reactions were recorded.
Results There was no significant difference in VAS pain score and pressing times of analgesic pump between the two groups. Compared with sufentanil group, the incidence of nausea and vomiting in nabufen group was significantly lower (P < 0.01), Ramsay sedation score increased significantly 8-48 h after administration (P < 0.05), and patients′ satisfaction with the effect of PCIA increased significantly (P < 0.05), but the incidence of hypotension and bradycardia had no significant difference.
Conclusion Intravenous analgesia with nabufen after retroperitoneal endoscopy is comparable to sufentanil, but with fewer adverse reactions and higher patient satisfaction. |
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