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| 疼痛敏感性及阿片类镇痛药用量与多巴胺转运体基因多态性的相关性 |
| Association of single nucleotide polymorphisms of DAT1 with pain sensitivity and postoperative opioids dose |
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| DOI：10.12089/jca.2019.12.002 |
| 中文关键词: 多巴胺转运体 基因多态性 术后疼痛 阿片类 |
| 英文关键词: Dopamine transporter Gene polymorphism Postoperative pain Opioids |
| 基金项目:新疆维吾尔自治区自然科学基金（2017D01C171） |
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| 中文摘要: |
目的 探讨多巴胺转运体(dopamine transporter, DAT)基因(DAT1)多态性对疼痛敏感性及阿片类镇痛药用量的影响。
方法 选择择期上腹部手术的汉族患者121例,抽取患者外周静脉血通过聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测DAT1可变串联重复（VNTR）多态性,利用便携式压力测试仪对患者试验性疼痛压力痛阈(PPT)和压力耐痛阈(PTO)进行检测,记录患者术后阿片类镇痛药用量,分析患者的生物社会学特征和DAT1 VNTR多态性与疼痛敏感性和术后阿片类镇痛药用量的关系。
结果 121例患者中,DAT1 VNTR等位基因的分布频率分别为9R(18.2％)、10R(81.8％),基因型分布频率分别为9R/9R(7.4％)、9R/10R(21.5％)、10R/10R(71.1％)。不同DAT1 VNTR等位基因型患者PPT和PTO差异无统计学意义,术后24 h和48 h阿片类药物用量差异无统计学意义。不同DAT1 VNTR等位基因型患者中,40岁以下患者的PTO明显高于65岁以上的患者(P<0.05),阿片类镇痛药用量明显多于65岁以上患者(P<0.05)。
结论 DAT1 VNTR多态性可能与疼痛敏感性及术后阿片类镇痛药用量无关。 |
| 英文摘要: |
Ojective To explore the influence of dopamine transporter (DAT1) polymorphisms on pain sensitivity and postoperative opioids requirements in postoperative pain patients.
Methods We enrolled 121 Chinese Han population patients scheduled to undergo upper abdominal surgery, and then the pressure pain threshold (PPT) and the pain tolerance domain (PTO) of patients were detected by stress stimulation. The DAT1 gene polymorphism was detected by collecting venous blood and polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP). The postoperative analgesic requirement of opioids was recorded after operation. The characteristics of patients and DAT1 gene polymorphism were analyzed to investigate whether these factors contributed to the variability of experimental pain sensitivity and postoperative opioids dose.
Results In 121 patients, the distribution frequency of DAT1 VNTR allele was 9R (18.2%), 10R (81.8%), and the distribution frequency of genotype patients was 9R/9R (7.4%), 9R/10R (21.5%), and 10R/10R (71.1%). There was no association between DAT1 VNTR gene polymorphism, PPT, PTO and opioids dose. Patients had different DAT1 VNTR gene polymorphism, patients under 40 years old had significantly higher PTO compared to those over or at the age of 65 years (P < 0.05), patients under 40 years old needed higher opioids dose compared with those over or at the age of 65 years (P < 0.05).
Conclusion The DAT1 VNTR polymorphism may be not associated with PPT, PTO and opioids dose. |
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