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| 昂丹司琼预防麻醉后寒战有效性和安全性的Meta分析 |
| Efficiency and safety of ondansetron in preventing postanaesthesia shivering：a meta-analysis |
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| DOI：10.12089/jca.2019.08.016 |
| 中文关键词: 昂丹司琼 麻醉后寒战 有效性 安全性 Meta分析 |
| 英文关键词: Ondansetron Post-anesthesia shivering Efficiency Safety Meta-analysis |
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| 中文摘要: |
目的 评价昂丹司琼预防麻醉后寒战的有效性和安全性。
方法 计算机检索Cochrane Library、PubMed、Embase、CNKI、万方、维普等数据库，检索时间为建库至2018年8月，纳入以昂丹司琼预防麻醉后寒战为研究目的，研究组为昂丹司琼，对照组为生理盐水或哌替啶或曲马多的随机对照试验，采用RevMan 5.3对数据进行Meta分析，根据不同对照组、不同麻醉方式及不同剂量进行亚组分析。
结果 共纳入16项研究，1 443例受试者。有效性方面，研究组寒战发生率明显低于生理盐水组（RR=0.42，95%CI 0.35~0.51，P＜0.001）；与哌替啶组（RR=0.68，95%CI 0.44~1.05，P=0.09）及曲马多组（RR=2.07，95%CI 0.90~4.75，P=0.09）差异无统计学意义；在3个不同麻醉方式亚组（RR=0.44，95%CI 0.36~0.54，P＜0.001），2个不同剂量亚组（RR=0.41，95%CI 0.34~0.49，P＜0.001）中，研究组寒战发生率明显低于生理盐水组。安全性方面，研究组术后恶心呕吐发生率明显低于生理盐水组（RR=0.27，95%CI 0.16~0.46，P＜0.001）。
结论 昂丹司琼可有效预防麻醉后寒战的发生,其效果与哌替啶、曲马多相当，并且可明显减少术后恶心呕吐的发生。 |
| 英文摘要: |
Objective To evaluate the efficiency and safety of ondansetron in preventing postanesthesia shivering (PAS).
Methods Using the computer to search the Cochrane Library, Pubmed, Embase and CNKI, WanFang, VIP databases. The time range of the search is from inception to August 2018. Randomized controlled trials （RCTs） that evaluated the efficiency and safety of ondansetron in the prevention of PAS were included in the Meta analysis. The experimental group was ondansetron, the control group was a placebo (saline) or pethidine or tramadol. RevMan 5.3 was used to perform the meta-analysis. Subgroup analysis was performed according to different control groups, different anesthesia methods and different doses.
Results Sixteen RCTs with a total of 1 443 subjects were included. Compared with placebo (saline), ondansetron was associated with a significant reduction of PAS (RR = 0.42, 95% CI 0.35-0.51, P < 0.001); compared with meperidine group (RR = 0.68, 95% CI 0.44-1.05, P = 0.09) and tramadol group (RR = 2.07, 95% CI 0.90-4.75, P = 0.09), there was no statistical difference; in three different anesthesia subgroups (RR = 0.44, 95% CI 0.36-0.54, P < 0.001), in two different dose subgroups (RR = 0.41, 95% CI 0.34-0.49, P < 0.001), the incidence of shivering in the ondansetron group was significantly lower than in the placebo group. The incidence of nausea and vomiting was significantly lower in the ondansetron group than in the placebo group (RR = 0.27, 95% CI 0.16-0.46, P < 0.001).
Conclusion Ondansetron can prevent PAS effectively, the effect is comparable to meperidine, tramadol, and significantly reduce the risk of postoperative nausea and vomiting. |
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