Ojective To observe effect of propofol or sevoflurane on sleep quality and melatonin secretion after general anesthesia.
Methods A total of 120 cases of gynecologic laparoscopic surgery with age 18 - 49 years old, BMI 18.5 - 25 kg/m2 , falling into ASA physical status Ⅰor Ⅱ, were randomly divided into two groups: propofol group ( group P) and sevoflurane group (group S) via random number table. Induction of anesthesia were the same. Group P maintained the anesthesia via target control input of propofol which dose was 4 - 12 mg·kg-1·h-1 and during the surgery intermittent intravenous injection of sufentanyl 0.2 μg/kg, cisatracurium 0.1 mg/kg, were conducted to keep the BIS index 40 - 60. Group S inhaled sevoflurane （MAC 1.0 - 1.3）, giving intermittent intravenous sufentanyl 0.2 μg/kg, cisatracurium 0.1 mg/kg, to maintain the BIS index 40 - 60. The Pittsburgh sleep quality index (PSQI) and the concentration of melatonin in morning urine were observed preoperative and postoperative 1, 3, 7 and 30 days.
Results Intra-group comparison: group P showed significant increases in PSQI on the 1st and 3rd days postoperative compared with preoperative (P < 0.05), at the same time, melatonin concentrations decreased significantly (P < 0.05). Group S showed a marked increase in PSQI on the 1st day postoperation compared with preoperation (P < 0.05), and the corresponding melatonin concentrations decreased significantly (P < 0.05). Inter-group comparison: PSQI was significantly higher in group P on the 1st and 3rd days after operation than that in group S, and melatonin concentrations was obviously lower in group S (P < 0.05).
Conclusion Propofol and sevoflurane have a significant effect on the quality of sleep after general anesthesia, but the time of effect of sevoflurane on the quality of sleep is shorter than that of propofol. |
