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| 复合羟考酮时老年患者无痛宫腔镜检查依托咪酯的半数有效剂量 |
| Median effective dose of etomidate combined with oxycodone for painless hysteroscopy in senile patients |
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| DOI：10.12089/jca.2019.05.008 |
| 中文关键词: 羟考酮 依托咪酯 宫腔镜 老年 半数有效剂量 |
| 英文关键词: Oxycodone Etomidate Hysteroscopy Elderly Median effective dose |
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| 中文摘要: |
目的 观察复合羟考酮时老年患者无痛宫腔镜检查依托咪酯的半数有效剂量（ED50）。
方法 选择34例2017年8—11月行宫腔镜检查的老年患者，年龄66~74岁，体重45~58 kg，ASA Ⅱ 或 Ⅲ级。静脉给予0.06 mg/kg羟考酮，2 min后给予依托咪酯，患者意识消失后行宫腔镜检查。采用Dixon's up-and-down法计算依托咪酯的ED50。设定依托咪酯0.2 mg/kg为初始剂量，如果检查中出现皱眉或体动反应，下一患者增加剂量，反之降低剂量，相邻剂量比为1∶1.2。采用概率单位法计算依托咪酯ED50及其95%可信区间（CI）。
结果 复合羟考酮时老年患者无痛宫腔镜检查依托咪酯ED50为0.21 mg/kg（95%CI 0.18~0.25 mg/kg）。
结论 复合羟考酮时老年患者无痛宫腔镜检查依托咪酯的ED50为0.21 mg/kg。 |
| 英文摘要: |
Ojective To observe the median effective dose (ED50) of etomidate combined with oxycodone for painless hysteroscopy in senile patients.
Methods From August 2017 to November 2017, thirty-four elderly patients undergoing hysteroscopy, aged 66-74 years, weighing 45-58 kg, falling into ASA physical status Ⅱor Ⅲ, were enrolled in this study. Etomidate was injected two minutes after injection with oxycodone (0.06 mg/kg), and then hysteroscopy was implemented when their consciousness disappeared. The ED50 of etomidate was calculated using Dixon's up-and-down method and initial dose was 0.2 mg/kg. A higher level of dosage was used if the last patient has a frown or somatic reaction, a lower level of dosage was used if the last patient has not a frown or somatic reaction, and the ratio of adjacent dosage was 1∶1.2. The probability unit method was used to determine the ED50 and 95% confidence interval of etomidate.
Results For hysteroscopy, the ED50 and 95% confidence interval of etomidate combined with oxycodone in senile patients was 0.21 mg/kg (0.18-0.25 mg/kg).
Conclusion The ED50 of etomidate combined with oxycodone for painless hysteroscopy in elderly patients is 0.21 mg/kg. |
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