Ojective To analyze the change of different PETCO2 on regional cerebral oxygen saturation (rScO2) and cerebral blood flow in infants with ventricular septal defect repair. Methods In this study, 60 infants with VSD were randomly divided into high ventilation group (group H, 30 cases) and low ventilation group (group L, 30 cases). PETCO2 was maintained at 40 - 45 mmHg by regulating VT and RR in group L. PETCO2 was maintained at 35 - 40 mmHg by regulating VT and RR in group H. The values of rScO2, flow velocity of middle cerebral artery (VMCA) at the right side, pulse index (PI) and resistance index(RI) were recorded respectively after anesthesia (T0), cut pericardium (T1), the end of CPB (T2), the end of modified ultrafiltration (T3), after operation (T4). Results Compared with T2, the values of rScO2 and VMCA were significantly increased while the levels of PI and RI were decreased at T0, T1, T3, T4 (P<0.05). Meanwhile, the levels of rScO2 and VMCA in group L were higher than those in group H (P<0.05). Conclusion The infants' rScO2 and VMCA performed better when PETCO2 is 40-45 mmHg versus 35-40 mmHg, which could improve the balance of cerebral oxygen supply and demand. |