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| 不同剂量羟考酮复合依托咪酯用于老年患者无痛胃镜检查的效果 |
| Analgesic effect of different doses of oxycodone mixed with etomidate for old patient in gastroscopy |
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| DOI：10.12089/jca.2019.04.016 |
| 中文关键词: 羟考酮 依托咪酯 胃镜检查 老年 |
| 英文关键词: Oxycodone Etomidate Gastroscopy Elderly |
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| 中文摘要: |
目的 观察不同剂量羟考酮复合依托咪酯用于老年患者无痛胃镜检查的效果。
方法 选择2017年2—11月全麻下行无痛胃镜检查的老年患者120例，男62例，女58例，年龄65～79岁，体重46～68 kg，ASA Ⅰ—Ⅲ级，随机分为四组，每组30例：羟考酮1组（O1组）、羟考酮2组（O2组）、羟考酮3组（O3组）及对照组（C组）。O1、O2、O3组分别静脉注射羟考酮0.025、0.05、0.075 mg/kg，C组静脉注射等容量生理盐水，2 min后四组静脉注射依托咪酯0.2 mg/kg。术中出现呛咳或体动反应时，静脉追加依托咪酯0.1 mg/kg。记录胃镜检测时间;追加依托咪酯的情况;记录呛咳、体动、呼吸抑制、头晕、恶心呕吐、肌震颤等不良反应的发生情况。
结果 O1、O2和O3组追加依托咪酯例数明显少于C组 (P<0.05)；O2和O3组追加依托咪酯例数明显少于O1组 (P<0.05)。O1、O2和O3组呛咳、体动、恶心呕吐和肌震颤发生率明显低于C组 (P<0.05)；O2和O3组呛咳、体动、恶心呕吐和肌震颤发生率明显低于O1组 (P<0.05)。O3组呼吸抑制和头晕发生率明显高于C、O1和O2组（P<0.05）。
结论 羟考酮0.025、0.05、0.075 mg/kg复合依托咪酯用于老年患者无痛胃镜检查，其中羟考酮0.05 mg/kg更为安全有效。 |
| 英文摘要: |
Objective To investigate the analgesic effect of different doses of oxycodone mixed with etomidate for old patient in gastroscopy.
Methods A total of 120 elderly patients underwent painless gastroscopy from February 2017 to November 2017, 62 males and 58 females, aged 65-79 years, weighing 46-68 kg, ASA physical status Ⅰ-Ⅲ, were randomly divided into four groups (n=30): oxycodone 1 group (group O1), oxycodone 2 group (group O2), oxycodone 3 group (group O3), and control group (group C). The aged were intravenously injected respectively with oxycodone (0.025, 0.05 and 0.075 mg/kg) in group O1, group O2, group O3 and 0.9% NaCl in group C. And then, all people were intravenously injected with etomidate (0.2 mg/kg). When cough or movement occurred during gastroscopy, etomidate (0.1 mg/kg) was intravenously injected additionally. The occurrence of cough, body movement, respiratory depression, dizziness, nausea and vomiting and myoclonus were recorded.
Results Compared with the group C, the number of additional etomidate in group O1, group O2 and group O3 significantly decreased (P<0.05); compared with group O1, the number of additional etomidate decreased in group O2 and group O3 (P<0.05). Compared with group C, the incidence of cough, movement, nausea and vomiting and myoclonus in group O1, group O2, and group O3 were lower (P<0.05); compared with group O1, the incidence of cough, movement, nausea and vomiting and myoclonus decreased in group O2 and group O3 (P <0.05). The incidence of respiratory depression and dizziness in group O3 was higher than that in group C, group O1 and group O2 (P<0.05).
Conclusion Oxycodone 0.05 mg/kg mixed with etomidate was safe and effective for old patient in gastroscopy. |
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