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| 吸烟对无痛胃镜检查男性患者丙泊酚用量的影响 |
| Clinical observation of propofol dose in male smokers undergoing painless gastroscopy |
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| DOI：10.12089/jca.2018.11.013 |
| 中文关键词: 吸烟 丙泊酚 胃镜 |
| 英文关键词: Smoking Propofol Gastroscopy |
| 基金项目: |
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| 中文摘要: |
目的 研讨吸烟对丙泊酚麻醉下胃镜检查男性患者丙泊酚用量的影响。
方法 行无痛胃镜检查男性患者80例,年龄40～50岁,ASA Ⅰ或Ⅱ级,按照吸烟与否分为非吸烟组(NS组)和吸烟组(S组),每组40例。静脉注射丙泊酚至BIS降至60及以下时停止首次给药;患者出现不良反应且影响操作时或BIS＞64时追加丙泊酚0.5 mg/kg,记录丙泊酚诱导量和追加例次,胃镜操作时间、苏醒及定向力恢复时间，恶心呕吐发生情况，呛咳、喉痉挛等呼吸道不良反应和其它不良事件发生情况。
结果 S组丙泊酚诱导量明显高于NS组(P<0.05)，追加次数明显多于NS组（P<0.05）,S组出现术后恶心呕吐发生率明显低于NS组(P<0.05),S组呼吸道不良事件发生率高于NS组(P<0.05)。
结论 在无痛胃镜检查过程中,吸烟增加了男性受检者的丙泊酚的用药量,及术中追加丙泊酚次数,同时呼吸道不良反应发生率增加。 |
| 英文摘要: |
Objective To investigate the effect of propofol dosage in male smokers undergoing gastroscopy under propofol anesthesia.
Methods Eighty patients, aged 40 - 50 years, falling into ASA physical status Ⅰ-Ⅱ, undergoing gastroscopy were randomly divided into two groups (n = 40 each): non-smoking group (group NS) and smoking group (group S). All patients were continuously monitored by BIS. When BIS was 60, the induced dose of propofol was stoped and the amount of propofol was recorded. When adverse reactions impacted the operation or when BIS was greater than 64, additional propofol from 30 to 50 mg was injected. Then the amount of propofol induction and additional cases were recorded, as well as the time of gastroscope operation, recovery time and adverse reactions, including nausea, vomiting, respiratory tract (cough, throat) and other adverse reaction were compared.
Results The amount of propofol induced and the additional timesof group S were significantly higher than group NS (P < 0.05)， 9 cases of nausea and vomiting occurred in group NS, only 1 case of nausea and vomiting occurred in group S,the incidence of postoperative nausea and vomiting in group S were significantly lower than group NS (P < 0.05), the incidence of airway adverse events with group S was higher than group NS (P < 0.05).
Conclusion During the painless gastroscopy, smoking increased the dose of propofol in male subjects and the number of propofol additions during surgery, while the incidence of respiratory adverse reactions increased. |
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