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| 右美托咪定与丙泊酚麻醉诱导时的协同作用 |
| Interactive effect between dexmedetomidine and propofol for sedation induction |
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| DOI：10.12089/jca.2018.05.003 |
| 中文关键词: 右美托咪定 丙泊酚 半数有效剂量 |
| 英文关键词: Dexmedetomidine Propofol Median effective dose |
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| 中文摘要: |
| 目的 评价右美托咪定和丙泊酚麻醉诱导时镇静作用的相互影响。方法 择期全麻手术患者75例,男36例，女39例，年龄18～65岁，BMI 20～25 kg/m2，ASA Ⅰ或Ⅱ级，采用随机数字表法均分为三组, 每组25例: 丙泊酚组(A组)、右美托咪定组(B组)、丙泊酚复合右美托咪定组(C组), 每组再根据不同药物剂量分为5个亚组, 相邻两组剂量等比为1.25, 采用点斜法计算ED50及其95％可信区间(CI)。结果 A组丙泊酚诱导剂量ED50为1.25 mg/kg(95％CI 0.90～1.45 mg/kg),B组右美托咪定麻醉诱导剂量ED50为1.35 μg/kg(95％CI 0.95～1.50 μg/kg), C组丙泊酚和右美托咪定诱导剂量ED50分别为0.65 mg/kg(95％CI 0.50～0.90 mg/kg)和0.40 μg/kg(95％CI 0.34～0.65 μg/kg)。等辐射分析法判定丙泊酚和右美托咪定之间在镇静效应上呈现协同作用。结论 右美托咪定复合丙泊酚可以产生明显的镇静效应协同作用。 |
| 英文摘要: |
| Ojective Evaluate the interaction between dexmedetomidine and propofol for sedation induction. Methods Seventy-five patients who undergoing elective surgery under general anesthesia, 36 males and 39 females, aged 18-65 years, BMI 20-25 kg/m2, ASA physical status Ⅰ or Ⅱ were randomly divided into three groups (n=25): propofol group (group A), dexmedetomidine group (group B), propofol combined dexmedetomidine group(group C), each group was divided into 5 groups according to different drug doses, the dose ratio of the adjacent two groups was 1.25, and the median effective dose (ED50) value was calculated by the point oblique method. Results The hypnotic dose of propofol ED50 in group A was 1.25 mg/kg (0.90-1.45 mg/kg), and the anesthetic induction dose of dexmedetomidine ED50 in group B was 1.35 μg/kg (0.95-1.50 μg/kg), and the hypnotic dose of propofol and dexmedetomidine ED50 in group C was 0.65 mg/kg (0.50-0.90 mg/kg) and 0.40 μg/kg (0.34-0.65 μg/kg) respectively. Conclusion Dexmedetomidine combined with propofol can produce a significant hypnotic effect, while reducing the impact on the circulation. |
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