文章摘要
中国西北部地区汉族患者麻醉药物相关基因多态性的分布
Frequency of aneathetics-related genetic polymorphism in the North-western Chinese population
  
DOI：10.12089/jca.2017.12.1149
中文关键词: 基因多态性  西北地区  汉族群体  频率
英文关键词: Genetic polymorphism  North-western China  Han population  Frequency
基金项目:第四军医大学军事医学提升计划（No.2016TSB-014）
作者单位E-mail
刘广林 710032,西安市,西京医院麻醉科  
路志红 710032,西安市,西京医院麻醉科  
陈敏 710032,西安市,西京医院麻醉科  
王洁茹 710032,西安市,西京医院麻醉科  
聂煌 710032,西安市,西京医院麻醉科  
董海龙 710032,西安市,西京医院麻醉科 hldong6@hotmail.com 
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中文摘要:
      
目的 对中国西北部地区汉族手术患者OPRM1、CYP3A4*1G、SLCO1B1 和ABCB1的基因型种类进行回顾, 明确与镇痛和肌松相关的基因突变率。
方法 西京医院2016年9月至2017年4月籍贯为西北地区省市(陕西、甘肃、宁夏、青海、新疆)的汉族手术患者3 213例, 男1 492例, 女1 721例, 对其OPRM1、CYP3A4*1G、SLCO1B1 和ABCB1基因多态性检测结果 进行回顾。
结果 OPRM1(118A>G)突变杂合子AG型的占比为42.11%, 突变纯合子GG型的占比为12.14%。CYP3A4*1G的CC、TT、TC、CT的占比分别为29.69%、4.17%、65.67%、0.47%。SLCO1B1杂合子AG型的占比为37.44%, GG型的占比为55.21%。ABCB1的CC、TT、TC、CT的占比分别为13.07%、44.60%、0.28%、42.05%。男性和女性各基因型分布差异无统计学意义。
结论 西北汉族手术患者中与芬太尼等阿片类药物和罗库溴铵用量相关的4个基因位点突变率均较高, 提示基因多态性序列测定指导麻醉用药具有重要临床价值。
英文摘要:
      
Objective To investigate the incidence of genotypes related to analgesia and muscle relax effects, and to review the genetic polymorphism of OPRM1, CYP3A4*1G, SLCO1B1 and ABCB1 in Han population in North-western China.
Methods The genotypes of OPRM1, CYP3A4*1G, SLCO1B1 and ABCB1 in patients born in North-western China between September, 2016 and May, 2017 were reviewed. North-western China was defined as Shaanxi, Gansu, Ningxia, Qinghai and Xinjiang Provinces. The distribution of genotypes was recorded. And the differences between male and female patients were compared.
Results The frequency was 42.11% for AG genotype and 12.14% for GG genotype of OPRM1 (118A>G). For CYP3A4*1G, the frequencies of CC, TT, TC and CT were 29.69%, 4.17%, 65.67% and 0.47%, respectively. For ABCB1, the frequencies of CC, TT, TC and CT were 13.07%, 44.60%, 0.28% and 42.05%, respectivsly. For SLCO1B1, AG genotype appeared in 37.44% of the patients, GG genotype appeared in 55.21% of the patients. There was no difference between the male and the female patients.
Conclusion Genotypes related to change of susceptibility to opioids including fentanyl and rocuronium were detected in high percentage of patients in North-western China, indicating that SNP assay for instruction of anesthetic practice be of value.
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