文章摘要
乙琥胺对七氟醚诱发幼鼠躁动的抑制作用
Inhibitory effect of ethosuximide on sevoflurane-induced emergence delirium in neonatal rats
  
DOI：
中文关键词: 七氟醚  乙琥胺  额叶  脑电功率谱  躁动
英文关键词: Sevoflurane  Ethosuximide  Frontal lobe  EEG power spectrum  Emergence delirium
基金项目:
作者单位E-mail
文雯 200092,上海交通大学医学院附属新华医院麻醉与重症医学科  
曹波 华东师范大学脑功能基因组学教育部重点实验室,上海市脑功能基因组学重点实验室  
沈峰岩 复旦大学附属华山医院麻醉科  
赵璇 200092,上海交通大学医学院附属新华医院麻醉与重症医学科 zhaoxuan0323@hotmail.com 
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中文摘要:
      
目的：观察乙琥胺对七氟醚诱发幼年大鼠躁动的抑制作用。
方法：SD大鼠,9～11日龄,体重17～23 g。取12只实验动物,随机分为生理盐水组(100 μl,腹腔注射)和乙琥胺组(4 mg/100 μl,腹腔注射), 每组6只。持续吸入1%七氟醚,每隔2分钟记录1次躁动评分(PAHBs评分),总观察时间为10 min。另取10只实验动物,同样分为生理盐水组(100 μl,腹腔注射)和乙琥胺组(4 mg/100 μl,腹腔注射),每组5只。持续吸入1%七氟醚,每隔2分钟监测1次额叶脑电功率谱强度值,总监测时间为10 min。
结果：1%七氟醚处理时2、4、6、8和10 min乙琥胺组PAHBs评分均明显低于生理盐水组(P<0.05),额叶脑电功率谱强度值明显低于生理盐水组(P<0.05)。
结论：乙琥胺可以降低七氟醚诱发躁动幼年大鼠的额叶脑电功率谱强度值,对七氟醚诱发的幼年大鼠躁动有明显的抑制作用。
英文摘要:
      
Objective: To investigate the inhibitory effect of ethosuximide, an antiepileptic drug, on sevoflurane-induced emergence delirium in neonatal rats.
Methods: Twelve SD rats (17-23 g) at postnatal day 9-11 were randomly divided into ethosuximide group (4 mg/100 μl, intraperitoneal injection, n=6) and saline group (100 μl, intraperitoneal injection, n=6). Then the pups were treated with 1% sevoflurane for 10 minutes and agitated behaviors was observed using PAHBs scoring method for every 2 minutes. Ten more pups were randomly divided into two groups as previously described. Then the pups were treated with 1% sevoflurane for 10 minutes and EEG power spectrum of frontal lobe was monitored for every 2 minutes.
Results: Both PAHBs scores and EEG power spectrum at 2 min, 4 min, 6 min, 8 min and 10 min were significantly decreased in ethosuximide group when comparing with saline group under 1% sevoflurane inhalation (P<0.05).
Conclusion: Ethosuximide can decrease frontal lobe EEG power spectrum in sevoflurane induced agitated rats and inhibit sevoflurane-induced emergence delirium in neonatal rats.
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