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| 丙泊酚靶控输注时羟考酮抑制气管插管反应的半数有效剂量 |
| ED50 of oxycodone inhibiting responses to endotracheal intubation together with target concentration infusion of propofol |
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| DOI： |
| 中文关键词: 羟考酮 丙泊酚 插管法,气管内 剂量效应关系,药物 |
| 英文关键词: Oxycodone Propofol Intubation, intratracheal Dose-response relationship, drug |
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| 中文摘要: |
目的：测定丙泊酚靶控输注时羟考酮抑制气管插管反应的半数有效剂量(ED50)。
方法：择期全麻下手术的患者,性别不限,年龄18～65岁, BMI 18.5～24.9 kg/m2,ASA Ⅰ或Ⅱ级,Mallampati Ⅰ或Ⅱ级。静脉顺序注射羟考酮、靶控输注丙泊酚血浆浓度4 μg/ml, BIS< 60时, 静注罗库溴铵0.9 mg/kg后行气管插管机械通气。采用改良Dixon序贯法进行试验, 羟考酮起始剂量0.2 mg/kg。若气管插管反应阳性, 则下一例增加剂量;反之, 则降低剂量, 相邻剂量比值为1∶1.1。气管插管反应阳性的标准: 插管后2 min内MAPmax或HRmax较基础值≥20%。采用加权概率法计算羟考酮抑制气管插管反应的ED50、ED95及其相应的95%可信区间(CI)。
结果：共有27例患者完成正式研究。羟考酮抑制气管插管反应的ED50为0.204 mg/kg,(95%CI 0.175～0.249 mg/kg),ED95为0.342 mg/kg(95%CI 0.287～0.409 mg/kg)。
结论：血浆靶控输注丙泊酚4 μg/ml时, 羟考酮抑制气管插管反应的ED50为0.204 mg/kg, ED95为0.342 mg/kg。 |
| 英文摘要: |
Objective: To determine ED50 and ED95 of oxycodone inhibiting responses to endotracheal intubation together with target concentration infusion of propofol.
Methods: ASA physical status Ⅰ or Ⅱ patients, aged 18-65 years, with body mass index 18.5-24.9 kg/m2, falling into Mallampati Score Ⅰ or Ⅱ, undergoing elective surgery under general anesthesia, were enrolled. Anesthesia was induced with intravenous injection of oxycodone, target concentration infusion of propofol with plasma concentration of 4 μg/ml and intravenous injection of rocuronium 0.9 mg/kg when BIS<60. The patients were endotracheally intubated and mechanically ventilated. The initial dose of oxycodone was 0.2 mg/kg. The dose of oxycodone was increased/decreased by ratio of 1.1 in the next patient by modified Dixon’s up-and-down method. The response to endotracheal intubation was defined as an increase in the maximum mean arterial pressure and/or the maxmium heart rate≥20% of the baseline value with 2 minute after intubation. Probit analysis was used for calculating ED50, ED95 and 95% confidence interval (CI) of oxycodone inhibiting responses to endotracheal intubation.
Results: There were twenty-seven patients who completed the test finally. ED50 and ED95 (95% CI) of oxycodone inhibiting responses to endotracheal intubation were respectively 0.204(0.175-0.249) mg/kg and 0.342(0.287-0.409) mg/kg.
Conclusion: When plasma target concentration of propofol 4 μg/ml is infused, ED50 and ED95 of oxycodone inhibiting responses to endotracheal intubation is 0.204 and 0.342 mg/kg, respectively. |
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