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| 羟考酮对慢性乙型肝炎剖宫产产妇术后T细胞功能的影响 |
| Effect of postoperative analgesia with oxycodone on T cell function after operative of cesarean section with chronic hepatitis B |
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| DOI： |
| 中文关键词: 羟考酮 剖宫产 慢性乙型肝炎 免疫功能 |
| 英文关键词: Oxycodone Cesarean section Chronic hepatitis B Immune function |
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| 中文摘要: |
目的 探讨羟考酮术后镇痛对慢性乙型肝炎剖宫产产妇术后T细胞功能的影响。
方法 择期在腰-硬联合麻醉下行剖宫产的慢性乙型肝炎产妇60例，年龄22～35岁，ASA Ⅰ或Ⅱ级，Child分级A或B，随机分为两组，每组30例。分别采用羟考酮0.8 mg/kg(O组)和吗啡0.8 mg/kg(M组)行术后静脉镇痛，镇痛泵配方均用生理盐水稀释至100 ml，背景量2 ml/h，Bolus 2 ml，锁定时间15 min。记录术毕即刻、术后24、48、72 h免疫细胞(Th1、Th2细胞)及生化指标。记录术后24 h内镇痛泵的按压次数和累计镇痛药用量。记录术后不良反应情况。
结果 术后24 h和48 h，O组Th1明显高于M组(P<0.05)；M组Th1、Th2细胞变化差异无统计学意义。O组总按压次数和镇痛药累计用量明显少于M组(P<0.05)。两组术后不良反应发生率差异无统计学意义。
结论 慢性乙型肝炎剖宫产产妇术后镇痛中羟考酮能激活T细胞，而吗啡引起Th1细胞抑制。 |
| 英文摘要: |
Objective To investigate the effect of postoperative analgesia with oxycodone on T cell function after operative of cesarean section with chronic hepatitis B.
Methods Sixty cesarean section women with chronic hepatitis B undergoing CS, aged 22-35, were randomly divided into two groups: oxycodone group (group O) and morphine group (group M). The changes of immune cells (Th1, Th2) and liver function were recorded after the analgesia (immediate, postoperative 24 h, 48 h, 72 h). The total number of pressing analgesia pump and the cumulative amount of PCA were recorded.
Results The Th1 of group O was higher than that of group M at 24 h,48 h after operation (P<0.05), while there was no significant difference of Th1 and Th2 in group M. The total patient-controlled pressing times and accumulated amount of PCA of group O were significantly lower than those in group M (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups.
Conclusion Oxycodone can activate T cell function in postoperative analgesia, while morphine causes the inhibition of Th1 cells. |
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