Objective To observe the effects of ketamine on the patients with depression receiving modified electric conulsive therapy (MECT).
Methods Sixty patients with depression were randomly divided into ketamine group and propofol group (n=30 each group). Atropine 0.5-1.0 mg, propofol 1.0 mg/kg or ketamine 0.8 mg/kg i.v. were given before MECT, Scoline 0.7-1.0 mg/kg i.v. was given after the eyelash reflex disappeared. Hamilton Depression Rating Scale (HAMD) was completed after the 2nd, 4th and 6th MECT, the time of convulsion, twitch index, energy percentage, respiratory recovery time and adverse reactions were recorded.
Results The total score of HAMD was significantly decreased with the increasing times of MECT in both groups, compared with propofol group, ketamine group’s HAMD total score decreased faster, especially after the 4th MECT, the score decreased significantly in ketamine group (P<0.05). The time of convulsion, twitch index, energy percentage, respiratory recovery time, adverse reactions all had no statistical significance between the two groups.
Conclusion Compered with propofol, ketamine, as an anesthetic of MECT, can effectively lower the score of HAMD. |
