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| 参附注射液对止血带引起的下肢缺血-再灌注肺损伤的影响 |
| Lung protective effect of Shenfu injection on the legs’ ischemia reperfusion injury |
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| DOI： |
| 中文关键词: 参附注射液 缺血-再灌注损伤 肺保护作用 |
| 英文关键词: Shenfu injection Ischemia-reperfusion injury Lung protective effect |
| 基金项目:南京市科技计划项目(201611004) |
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| 中文摘要: |
| 目的 探讨参附注射液对止血带引起的下肢缺血-再灌注肺损伤的影响。方法 选择行单侧下肢手术患者60例，男36例，女24例，ASA Ⅰ或Ⅱ级。将患者随机分为参附注射液组(SF组，n=32)和对照组(C组，n=28)。两组患者均采用腰-硬联合麻醉，给予 0.75％布比卡因1.5 ml，上电脑气压止血带(压力为300 mm Hg)止血。SF组于上止血带致缺血前30 min 静脉泵入参附注射液1 ml/kg (加入100 ml生理盐水中)，松止血带前5 min 再次泵入1 ml/kg (加入50 ml生理盐水中);C 组在相同时点分别静脉注射等量复方乳酸钠。记录上止血带前(T0)、松止血带后 5 min (T1) 、15 min (T2)、30 min (T3)的MAP和HR;采集静脉血测定血浆血栓素B2(TXB2)和丙二醛(MDA)浓度。结果 与T0时比较，T1～T3时两组MAP明显降低(P<0.05);T2、T3时SF组MAP明显高于C组(P<0.05)。两组患者HR组间组内差异均无统计学意义。T2、T3时SF组TXB2和MDA浓度明显低于C组(P<0.05或 P<0.01)。结论 参附注射液具有抗氧化作用，可减轻止血带所致的下肢缺血-再灌注肺损伤。 |
| 英文摘要: |
| Objective To discuss the lung protective effect of Shenfu injection on the legs’ ischemia-reperfusion injury. Methods Sixty patients (6 males, 24 females, ASA grade Ⅰ or Ⅱ)with unilateral lower limb surgery, were randomly divided into Shenfu injection group (group SF, n=32) and control group (group C, n=28). All patients were treated by combined spinal epidural anesthesia, with the same dose of local anesthetic (0.75％ bupivacaine 1.5 ml and the same pressure (300mm Hg) of tourniquet. Patients in group SF were given intravenous infusion of Shenfu injection with the dose of 1 ml/kg (added in normal saline 100 ml) 30 min before apply tourniquet and 1 ml/kg (added in nomal saline 50 ml) 5 min before tourniquet deflation. Patients in group C were injected with equal dose of compound sodium lactate at the same time. Recorded the hemodynamic changes before apply tourniquet (T0) and 5 min (T1), 15 min (T2) and 30 min (T3) after tourniquet deflation. Took venous blood to determine concentrations of plasma thromboxane B2 (TXB2) and malondialdehyde (MDA). Results Compared with T0, MAP in the two groups were significcantly lower at T1-T3 (P<0.05). MAP in group SF at T2 and T3 were higher than those in group C (P<0.05). There was no significant difference in HR between the two groups. TXB2 and MDA in group SF at T2 and T3 were significantly lower than those in group C (P<0.05 or P<0.01). Conclusion Shenfu injection with antioxidation has a protective effect on lower limb ischemia reperfusion lung injury induced by tourniquet. |
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